Search the Biochemistry and Molecular Biotechnology site

Biochemistry and Molecular Biotechnology Department

NOW HIRING an Academic Administrator - Open Rank!

Our mission is to illuminate the molecular mechanisms that govern basic biological processes, with an emphasis on integrative strategies to reveal fundamental mechanistic insights and develop new therapeutic paradigms empowered by a collaborative, diverse & inclusive community.

Who are we?

photo of a scientist holding a round bottom flask above the text trailblazers in biochemical research

two people looking at a transparent petri dish above the text mentors to the next generation of scientific changemakers

five people posing for a photo holding plates with food

Who are you?

Potential Students & Postdocs

Future Faculty

Prospective Staff

Community Member

Philanthropist

BMB Blog Posts

Jul 31, 2024

Celebrating RNA Day with Dr. Thoru Pederson

Join us (the BMB) in celebrating RNA Day by learning more about the innovative bioengineering by the Pederson Lab.

Read more
May 10, 2024

Dr. Brian Kelch Receives the Education Service Award, 2024

Dr. Brian Kelch received the Education Service Award in 2024! Learn more about his dedication to education in this blog post.

Read more

Check out more of our blogs here!

Latest News

Latest BMB news as reported by the UMass Chan Communications Office

Scientists at UMass Chan Medical School develop microRNA-based gene therapy that halts ALS progression in mice

July 29, 2026
Riccio Fund advances research projects in opioid tolerance, long-term memory storage

July 20, 2026
Biotech executives and venture capitalists come to UMass Chan to hear faculty start-up pitches

June 11, 2026
Cynthia Fuhrmann recognized with Distinguished Service Award from National Postdoctoral Association

March 17, 2026
UMass Chan awarded $800K to advance ALS research

March 12, 2026
4D Nucleome Consortium produces detailed models of the 3D genome over time in cells

January 07, 2026
Top story: UMass Chan celebrates naming of Paul J. DiMare Center

December 15, 2025
PhD candidate Emily Sholi receives grant to study pathogens’ impact on ribosomes

December 08, 2025
Chancellor Collins’ final Convocation address encourages optimism, determination

September 12, 2025
Inspired by faculty mentor, MD/PhD candidate pursuing dermatology

July 14, 2025
UMass Chan celebrates naming of Paul J. DiMare Center

July 10, 2025
Kristen Matteson and Mary Munson selected for Executive Leadership in Academic Medicine Program for Women

June 12, 2025
Morningside Graduate School of Biomedical Sciences honors students during annual awards ceremony

May 30, 2025
Educational Recognition Awards, Last Lecture celebrate UMass Chan’s collaborative environment

May 08, 2025
Origen Biotechnology funds research at UMass Chan to advance gene therapy technology

May 07, 2025
UMass Chan faculty present translational research at BRIDGE Fund Innovation Showcase

March 14, 2025

Check out more news here!

Recent Publications

Improved Purification of sgRNA and pegRNA by Use of a 5'-Terminal Dioctyloxytrityl (DOT) Protecting Group

Saturday, August 22, 2026

Author(s): Atish A Wagh,Jonathan K Watts

Source: The Journal of organic chemistry
Unmasking Wnt-driven HCC: Inhibiting SMYD2 to overcome immune resistance

Sunday, August 09, 2026

Author(s): Xiupeng Chen,Allison M Keeler,Joae Qiong Wu

Source: Molecular therapy. Oncology
Conformational asymmetry of human immunodeficiency virus-1 protease flaps increases along the darunavir drug resistance pathway

Wednesday, August 05, 2026

Author(s): Michel Guerrero,Roman Zadorozhnyi,Guowu Lin,Caitlin M Quinn,Guillermo Calero,Nese Kurt-Yilmaz,Celia A Schiffer,Tatyana Polenova,Angela M Gronenborn,Rieko Ishima

Source: Protein science : a publication of the Protein Society
A posttranslational modification of fimbriae drives pathogenicity in Klebsiella pneumoniae

Wednesday, July 29, 2026

Author(s): Genevieve S Dobihal,Kristen Lewis,Tian Huai Shen,Carmen M Herrera,Lisa Yu,Jonathan Barasch,M Stephen Trent,Josué Flores-Kim,Anne-Catrin Uhlemann

Source: Proceedings of the National Academy of Sciences of the United States of America
Functional interplay between H2B ubiquitylation and H2A.Z deposition

Tuesday, July 28, 2026

Author(s): Younus A Bhat,Ivano Mocavini,Erin O'Donnell,Song Tan,Oliver J Rando,Craig L Peterson

Source: The Journal of biological chemistry
MRI-Based Quantitative Evaluation of Tumor Ferroptosis Mediated by A Novel Self-Reducing Nano-Prodrug

Saturday, July 25, 2026

Author(s): Shuang Liu,Hewen Li,Yuhang Ding,Dengyi Duan,Lin Cao,Kangkang Liu,Wenyi Zhang,Shifeng Cheng,Yiming Li,Yunfei Guo,Xiang Qi,Jianmin Li,Xuening Zhang,Jing Peng,Gang Han,Yang Zhao

Source: Advanced healthcare materials
Epistemological parameters in the recent era of nuclear organization and function

Thursday, July 23, 2026

Author(s): Thoru Pederson

Source: Molecular biology of the cell
The WalRK two-component system in Streptococcus pneumoniae ensures robustness of secondary wall polymer attachment

Wednesday, July 22, 2026

Author(s): Justin J Zik,Zeyu Fu,Morgan N Price,Yujie Li,Qiao Yuan,Adam P Arkin,Adam M Deutschbauer,Josue Flores-Kim,Lok-To Sham

Source: mBio
Prioritizing neuroactive ligands using motif-guided virtual discovery and zebrafish profiling

Tuesday, July 21, 2026

Author(s): Ari B Ginsparg,Jaqueline A Martinez,Ishaan Patel,Angélique Buton,Laura T Lee,Raheel Sarwar,Rocco Moretti,Stephanie Puig,Summer B Thyme

Source: npj drug discovery
An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions

Friday, July 17, 2026

Author(s): Priyanka Madhu,Caroline Benz,Leandro Simonetti,Matthew J Winters,Mythili S Subbanna,Johanna Kliche,Lidia Gomez-Lucas,Hazem M Kotb,Izabella Krystkowiak,Dmitri Segal,William T P Darling,Sven Larsen-Lede...

Source: bioRxiv : the preprint server for biology
The Development of UM-232, a Covalent STING Antagonist

Tuesday, July 14, 2026

Author(s): Leonard Barasa,Leo DeOrsey,Maeve D O'Reilly,Sara E Cahill,Shruti Choudhary,Akumalla Allabaji,Srinivasa Rao Vidadala,Sujit Kumar Sarkar,Santoshkumar N Patil,Jeffrey Hale,Fiachra Humphries,Paul R Thomps...

Source: ACS medicinal chemistry letters
Ang2 and TAT targeting of leptomeningeal disease by the intravenous and intrathecal routes: a comparative analysis

Friday, July 10, 2026

Author(s): Chung-Fan Kuo,Tobi Babayemi,Kha Uyen Dam,Shaokuan Zheng,Hong Wei Yang,Rachael W Sirianni

Source: bioRxiv : the preprint server for biology
Intrathecal infusion of hypertonic fluid enables CSF Flow Enhancement (CFE) to facilitate nanoparticle delivery to the brain and spinal cord

Friday, July 10, 2026

Author(s): Oluwatobi Babayemi,Kha-Uyen Dam,Chung-Fan Kuo,Olivia Mihalek,Elena A Andreyko,Constance J Mietus,Shaokuan Zheng,Hong Wei Yang,Rachael W Sirianni

Source: bioRxiv : the preprint server for biology
Solvent-free Nanoparticle Assembly Protocol (SNAP): one-pot formulation of drug loaded polyester nanoparticles and their vessel size-dependent perivascular transport in the brain

Friday, July 10, 2026

Author(s): Elena A Andreyko,Miles Pourbaghi,Sarah E Stabenfeldt,Rachael W Sirianni

Source: bioRxiv : the preprint server for biology
A method to synthesize analytical rhodoquinone standards for quantitative analysis in tissue specimen

Thursday, July 09, 2026

Author(s): Thang Do,Akbar Ali,Jessica B Spinelli

Source: Journal of lipid research

A full list of department publications can be found here.

Social Media

Upcoming Events

Page Menu

Check out our upcoming seminars and events!

March 1512

FEB

APR

1512

Sun
Mon
Tue
Wed
Thu
Fri
Sat

1
2

3
4
5
6
7
8
9

10
11
12
13
14
15
16

17
18
19
20
21
22
23

24
25
26
27
28
29
30

31

Today