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Biochemistry and Molecular Biotechnology Department

Our mission is to illuminate the molecular mechanisms that govern basic biological processes, with an emphasis on integrative strategies to reveal fundamental mechanistic insights and develop new therapeutic paradigms empowered by a collaborative, diverse & inclusive community.

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BMB Blog Posts

Jul 31, 2024

Celebrating RNA Day with Dr. Thoru Pederson

Join us (the BMB) in celebrating RNA Day by learning more about the innovative bioengineering by the Pederson Lab.

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May 10, 2024

Dr. Brian Kelch Receives the Education Service Award, 2024

Dr. Brian Kelch received the Education Service Award in 2024! Learn more about his dedication to education in this blog post.

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Check out more of our blogs here!

Latest News

Latest BMB news as reported by the UMass Chan Communications Office

Chancellor Collins’ final Convocation address encourages optimism, determination

September 12, 2025
Inspired by faculty mentor, MD/PhD candidate pursuing dermatology

July 14, 2025
UMass Chan celebrates naming of Paul J. DiMare Center

July 10, 2025
Kristen Matteson and Mary Munson selected for Executive Leadership in Academic Medicine Program for Women

June 12, 2025
Morningside Graduate School of Biomedical Sciences honors students during annual awards ceremony

May 30, 2025
Educational Recognition Awards, Last Lecture celebrate UMass Chan’s collaborative environment

May 08, 2025
Origen Biotechnology funds research at UMass Chan to advance gene therapy technology

May 07, 2025
UMass Chan faculty present translational research at BRIDGE Fund Innovation Showcase

March 14, 2025
New research examines mechanisms of protein complex at basic cell biological level

January 14, 2025
PhD student among first to join UMass Chan program focused on quantitative skills

December 09, 2024
UMass Chan community invited to ponder meaning of ‘advancing together’ at art exhibit

September 25, 2024
UMass Memorial Health gift, with matching funds from UMass Foundation, to fund five new endowed chairs at UMass Chan

September 19, 2024
Convocation 2024: UMass Chan racing toward ambitious future

September 13, 2024
Morningside Graduate School of Biomedical Sciences celebrates largest class at qualifying exam ceremony

September 12, 2024
UMass Chan kicks off 2024 academic year with weeklong Convocation celebration

August 30, 2024
UMass Chan neuroscientist receives $4.1 million Transformative Research Award to study Down syndrome

July 16, 2024

Check out more news here!

Recent Publications

Total: 15 results

Normal Immune Function in a Newborn With Early Identification of a SAMD9 Mutation Presenting With Growth Restriction, Thrombocytopenia, and Primary Adrenal Insufficiency

Friday, November 21, 2025

Author(s): Kevin MingJie Gao,Qiu Yu Judy Huang,Polly Huang,Anum Muzaffar,Ramin Beheshti,Robert Wood,Jennifer Dantzer,Maria J Gutierrez

Source: Clinical case reports
Triazole-based STING inhibitors

Sunday, November 16, 2025

Author(s): Anju Singh,Leonard Barasa,Leo DeOrsey,Maeve D O'Reilly,Shruti Choudhary,Sara E Cahill,Thomas Rossetti,Robert Madison Green,Fiachra Humphries,Paul R Thompson

Source: Bioorganic & medicinal chemistry
PCNA is a nucleotide exchange factor for the clamp loader ATPase complex

Thursday, November 13, 2025

Author(s): Joshua Pajak,Jacob T Landeck,Xingchen Liu,Krishna Anand,Sasha Litvak,Brian A Kelch

Source: Proceedings of the National Academy of Sciences of the United States of America
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity

Friday, October 31, 2025

Author(s): Chengzhi Yu,Chen Wang,Taylor Forman,Jiale Xie,Samantha Major,Matthew X Fang,Jewel E Voyer,Joe Pogliano,Tian-Min Fu

Source: Molecular cell
Scaling back DEI programmes and the loss of scientific talent

Thursday, October 23, 2025

Author(s): Needhi Bhalla,JoAnn Trejo,Mary Munson

Source: Nature cell biology
David Baltimore and the advent of eukaryotic RNA binding proteins

Wednesday, October 22, 2025

Author(s): Thoru Pederson

Source: Molecular biology of the cell
Cellular infrastructure: X-rays have just made another soft landing

Wednesday, October 22, 2025

Author(s): Thoru Pederson

Source: Molecular biology of the cell
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing

Wednesday, October 15, 2025

Author(s): Dylan D Doxsey,Kuang Shen

Source: Proceedings of the National Academy of Sciences of the United States of America
Predicting the Impact of Drug Resistance Mutations on Inhibitor Potency with Molecular Dynamics and Machine Learning

Wednesday, October 15, 2025

Author(s): Lauren E Intravaia,Ala M Shaqra,Somayeh Pirhadi,Noa Popko,Nese Kurt Yilmaz,Celia A Schiffer

Source: The journal of physical chemistry. B
Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants

Monday, October 13, 2025

Author(s): Shilei Ding,Derek Yang,Irfan Ullah,Ling Niu,Matthew Unger,Marco A Díaz-Salinas,Monika Chandravanshi,Fei Zhou,Guillaume Beaudoin-Bussières,Mehdi Benlarbi,William D Tolbert,Keon-Woong Yoon,Ruixue Xu,Gen...

Source: Journal of virology
Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish

Friday, September 26, 2025

Author(s): Anna J Moyer,Summer B Thyme

Source: bioRxiv : the preprint server for biology
Next-Generation Multiplexed Targeted Proteomics Quantifies Post-Translational Modifications, Compound-Protein Interactions, and Disease Biomarkers with High Throughput

Friday, September 26, 2025

Author(s): Steven R Shuken,Geordon A Frere,Charlotte R Beard,Jesse D Canterbury,Nathan R Zuniga,Brandon M Gassaway,Shane L Dawson,Kean Hean Ooi,João A Paulo,M Windy McNerney,Steven P Gygi,Qing Yu

Source: bioRxiv : the preprint server for biology
Ending publication bias: A values-based approach to surface null and negative results

Wednesday, September 24, 2025

Author(s): Stephen Curry,Eunice Mercado-Lara,Virginia Arechavala-Gomeza,C Glenn Begley,Christophe Bernard,René Bernard,Stefano Bertuzzi,Needhi Bhalla,Dawn Bowers,Samuel Brod,Christopher Chambers,Michael R Doughe...

Source: PLoS biology
RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stability

Tuesday, September 23, 2025

Author(s): Vincent E Provasek,Albino Bacolla,Suganya Rangaswamy,Manohar Kodavati,Joy Mitra,Issa O Yusuf,Vikas H Malojirao,Velmarini Vasquez,Gavin W Britz,Guo-Min Li,Zuoshang Xu,Sankar Mitra,Ralph M Garruto,John ...

Source: Nucleic acids research
Nitrofuran-Based STING Inhibitors

Monday, September 22, 2025

Author(s): Leonard Barasa,Leo DeOrsey,Maeve D O'Reilly,Shruti Choudhary,Sara E Cahill,Anukriti Mathur,Sakshi Rajoria,Robert Madison Green,Akumalla Allabaji,Shreekrishna Nellikkalaya,Sourav Paul,Srinivasa Rao Vid...

Source: ACS omega

A full list of department publications can be found here.

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Upcoming Events

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Check out our upcoming seminars and events!

December 2025

NOV

JAN

2025

Sun
Mon
Tue
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Thu
Fri
Sat

1
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Dr. Daniel Bolon
Dr. Daniel Bolon 12pm

Event Description

Dr. Daniel Bolon

Room 816
4
5
RIPS Luo/Kaminta
RIPS Luo/Kaminta 4pm

Event Description

Jinyue Luo (Redding Lab)
Sylvester Kaminta (Kelch Lab)

LRB-816
6

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8
9
10
Dr. Karen Allen
Dr. Karen Allen 12pm
11
12
RIPS Petrossian/Hwang
RIPS Petrossian/Hwang 4pm

Event Description

Ed Petrossian (Li Lab)
Sungwoo Hwang (Thompson Lab)

LRB-816
13

14
15
16
17
Dr. Zuoshang Xu
Dr. Zuoshang Xu 12pm

Event Description

Dr. Zuoshang Xu

Room 816
18
19
NO RIPS
NO RIPS 4pm

Event Description

NO RIPS

LRB-816
20

21
22
23
24
No School -Christmas Eve
No School -Christmas Eve 4pm
25
No school - Christmas
No school - Christmas 8am
26
NO RIPS
NO RIPS 8am
27

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31

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