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Knowledge to cure

Our research is focused on identifying and characterizing new mechanisms of RNA regulation in the dynamic control of gene expression. We apply this knowledge to explore how RNA regulatory pathways impact stem cell pluripotency, mammalian development, growth, cancer, and neurological diseases. Ultimately we aim to exploit this understanding for the development of new therapeutic approaches for cancer and degenerative disease.

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Research Overview

We aim to discover novel mechanisms and pathways of RNA regulation with the goal of developing new therapies for cancer and other diseases.

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Current Research

Ongoing research projects in the lab seek to understand how RNA regulation, modification, and metabolism play a role in development and disease.

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Discoveries

We have made significant contributions to the areas of miRNA biogenesis and function, RNA metabolism, and RNA methylation and epitranscriptomics.

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Getting Results…
  • UMass Chan leads new $4.4 million study to study melanoma

    UMass Chan leads new $4.4 million study to study melanoma

    UMass Chan Medical School received a five-year, $4.4 million National Cancer Institute grant to study how transfer RNAs may fuel the spread of melanoma.

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  • Science, strength and survival: UMass Chan researcher, cancer patient inspires at 2025 UMass Cancer Walk

    Science, strength and survival: UMass Chan researcher, cancer patient inspires at 2025 UMass Cancer Walk

    The 27th annual UMass Cancer Walk at Polar Park raised more than $450,000 to support cancer research and clinical trials at UMass Chan.

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  • Chancellor Collins’ final Convocation address encourages optimism, determination

    Chancellor Collins’ final Convocation address encourages optimism, determination

    Four faculty members were honored with chancellor's medals at the annual Convocation and Investiture ceremony. 

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  • UMass Chan celebrates start of academic year with Convocation Week 2025

    UMass Chan celebrates start of academic year with Convocation Week 2025

    Festivities kick off on Friday, Sept. 5, with the T.H. Chan School of Medicine White Coat Ceremony.

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  • Richard Gregory named chair of molecular, cell & cancer biology

    Richard Gregory named chair of molecular, cell & cancer biology

    Richard I. Gregory, PhD, will join UMass Chan Medical School as the next chair of the Department of Molecular, Cell & Cancer Biology, beginning in December.

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