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Total: displaying 10 out of 100 results
  • Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50

    Friday, April 04, 2025
    Author(s): Sarah N Zvornicanin,Ala M Shaqra,Julia Flynn,Heidi Carias Martinez,Weiping Jia,Stephanie Moquin,Dustin Dovala,Daniel N Bolon,Nese Kurt Yilmaz,Celia A Schiffer
    Source: mBio
  • Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease

    Saturday, January 25, 2025
    Author(s): Vincent N Azzolino,Ala M Shaqra,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Viruses
  • Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability

    Tuesday, January 21, 2025
    Author(s): Jenna M Whalen,Jillian Earley,Christi Wisniewski,Arthur M Mercurio,Sharon B Cantor
    Source: Nature cancer
  • Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

    Wednesday, December 11, 2024
    Author(s): Benedikt M Mortzfeld,Shakti K Bhattarai,Vanni Bucci
    Source: eLife
  • G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis

    Monday, November 18, 2024
    Author(s): Srinivas Pittala,Dhanush Haspula,Yinghong Cui,Won-Mo Yang,Young-Bum Kim,Roger J Davis,Allison Wing,Yaron Rotman,Owen P McGuinness,Asuka Inoue,Jürgen Wess
    Source: Nature communications
  • Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance

    Saturday, September 28, 2024
    Author(s): Vincent N Azzolino,Ala M Shaqra,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Viruses
  • Commensal consortia decolonize Enterobacteriaceae via ecological control

    Wednesday, September 18, 2024
    Author(s): Munehiro Furuichi,Takaaki Kawaguchi,Marie-Madlen Pust,Keiko Yasuma-Mitobe,Damian R Plichta,Naomi Hasegawa,Takashi Ohya,Shakti K Bhattarai,Satoshi Sasajima,Yoshimasa Aoto,Timur Tuganbaev,Mizuki Yaginuma,Masahiro Ueda,Nobuyuki Okahashi,Kimiko Amafuji,Yuko Kiridoshi,Kayoko Sugita,Martin Stražar,Julian Avila-Pacheco,Kerry Pierce,Clary B Clish,Ashwin N Skelly,Masahira Hattori,Nobuhiro Nakamoto,Silvia Caballero,Jason M Norman,Bernat Olle,Takeshi Tanoue,Wataru Suda,Makoto Arita,Vanni Bucci,Koji Atarashi,Ramnik J Xavier,Kenya Honda
    Source: Nature
  • Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis

    Friday, April 26, 2024
    Author(s): Esteban J Rozen,William Frantz,Kim Wigglesworth,Theadora Vessella,Hong S Zhou,Jason M Shohet
    Source: Molecular cancer therapeutics
  • FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

    Sunday, March 24, 2024
    Author(s): Ke Cong,Nathan MacGilvary,Silviana Lee,Shannon G MacLeod,Jennifer Calvo,Min Peng,Arne Nedergaard Kousholt,Tovah A Day,Sharon B Cantor
    Source: Nature communications
  • Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics

    Thursday, March 14, 2024
    Author(s): Mariana Noto Guillen,Carmen Li,Brittany Rosener,Amir Mitchell
    Source: Science (New York, N.Y.)
  • Contributions of Hyperactive Mutations in M(pro) from SARS-CoV-2 to Drug Resistance

    Tuesday, March 12, 2024
    Author(s): Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
    Source: ACS infectious diseases
  • Functional Assay for Measuring Bacterial Degradation of Gemcitabine Chemotherapy

    Monday, September 18, 2023
    Author(s): Serkan Sayin,Amir Mitchell
    Source: Bio-protocol
  • Development of ADS051, an oral, gut-restricted, small molecule neutrophil modulator for the treatment of neutrophil-mediated inflammatory diseases

    Saturday, July 01, 2023
    Author(s): Christopher K Murphy,Bharat Dixit,Frederick B Oleson,Roland E Dolle,Ronald Farquhar,Beth A McCormick
    Source: FEBS open bio
  • Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease

    Friday, June 30, 2023
    Author(s): Julia M Flynn,Qiu Yu J Huang,Sarah N Zvornicanin,Gila Schneider-Nachum,Ala M Shaqra,Nese Kurt Yilmaz,Stephanie A Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
    Source: ACS infectious diseases
  • HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues

    Saturday, May 27, 2023
    Author(s): Gordon J Lockbaum,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Desaboini Nageswara Rao,Ean Spielvogel,Sook-Kyung Lee,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
    Source: European journal of medicinal chemistry
  • Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

    Wednesday, March 15, 2023
    Author(s): Ean Spielvogel,Sook-Kyung Lee,Shuntai Zhou,Gordon J Lockbaum,Mina Henes,Amy Sondgeroth,Klajdi Kosovrasti,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer,Ronald Swanstrom
    Source: eLife
  • Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells

    Friday, February 03, 2023
    Author(s): Serkan Sayin,Brittany Rosener,Carmen G Li,Bao Ho,Olga Ponomarova,Doyle V Ward,Albertha J M Walhout,Amir Mitchell
    Source: eLife
  • Mutational fitness landscape and drug resistance

    Monday, January 09, 2023
    Author(s): Julia Flynn,Neha Samant,Gily Schneider-Nachum,Tsepal Tenzin,Daniel N A Bolon
    Source: Current opinion in structural biology
  • Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes

    Tuesday, November 29, 2022
    Author(s): Scott M Leighow,Ben Landry,Michael J Lee,Shelly R Peyton,Justin R Pritchard
    Source: Cellular and molecular bioengineering
  • Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

    Saturday, November 19, 2022
    Author(s): Atanu Maiti,Adam K Hedger,Wazo Myint,Vanivilasini Balachandran,Jonathan K Watts,Celia A Schiffer,Hiroshi Matsuo
    Source: Nature communications
  • Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

    Monday, August 15, 2022
    Author(s): Sage E Foley,Michael J Dente,Xuqiu Lei,Benjamin F Sallis,Ethan B Loew,Mario Meza-Segura,Katherine A Fitzgerald,Beth A McCormick
    Source: mBio
  • Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

    Tuesday, June 21, 2022
    Author(s): Ala M Shaqra,Sarah N Zvornicanin,Qiu Yu J Huang,Gordon J Lockbaum,Mark Knapp,Laura Tandeske,David T Bakan,Julia Flynn,Daniel N A Bolon,Stephanie Moquin,Dustin Dovala,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Nature communications
  • Comprehensive fitness landscape of SARS-CoV-2 M(pro) reveals insights into viral resistance mechanisms

    Monday, June 20, 2022
    Author(s): Julia M Flynn,Neha Samant,Gily Schneider-Nachum,David T Barkan,Nese Kurt Yilmaz,Celia A Schiffer,Stephanie A Moquin,Dustin Dovala,Daniel N A Bolon
    Source: eLife
  • Transfusing Convalescent Plasma as Post-Exposure Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Double-Blinded, Phase 2 Randomized, Controlled Trial

    Tuesday, May 17, 2022
    Author(s): Shmuel Shoham,Evan M Bloch,Arturo Casadevall,Daniel Hanley,Bryan Lau,Kelly Gebo,Edward Cachay,Seble G Kassaye,James H Paxton,Jonathan Gerber,Adam C Levine,Arash Naeim,Judith Currier,Bela Patel,Elizabeth S Allen,Shweta Anjan,Lawrence Appel,Sheriza Baksh,Paul W Blair,Anthony Bowen,Patrick Broderick,Christopher A Caputo,Valerie Cluzet,Marie Elena Cordisco,Daniel Cruser,Stephan Ehrhardt,Donald Forthal,Yuriko Fukuta,Amy L Gawad,Thomas Gniadek,Jean Hammel,Moises A Huaman,Douglas A Jabs,Anne Jedlicka,Nicky Karlen,Sabra Klein,Oliver Laeyendecker,Karen Lane,Nichol McBee,Barry Meisenberg,Christian Merlo,Giselle Mosnaim,Han-Sol Park,Andrew Pekosz,Joann Petrini,William Rausch,David M Shade,Janna R Shapiro,J Robinson Singleton,Catherine Sutcliffe,David L Thomas,Anusha Yarava,Martin Zand,Jonathan M Zenilman,Aaron A R Tobian,David J Sullivan
    Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • Materials-driven approaches to understand extrinsic drug resistance in cancer

    Thursday, April 21, 2022
    Author(s): Justin R Pritchard,Michael J Lee,Shelly R Peyton
    Source: Soft matter
  • Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

    Sunday, February 20, 2022
    Author(s): Jacqueto Zephyr,Desaboini Nageswara Rao,Sang V Vo,Mina Henes,Klajdi Kosovrasti,Ashley N Matthew,Adam K Hedger,Jennifer Timm,Elise T Chan,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Journal of molecular biology
  • Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y

    Wednesday, January 19, 2022
    Author(s): Li Jiang,Neha Samant,Ping Liu,Mohan Somasundaran,Jeffrey D Jensen,Wayne A Marasco,Timothy F Kowalik,Celia A Schiffer,Robert W Finberg,Jennifer P Wang,Daniel N A Bolon
    Source: Journal of virology
  • Viral proteases: Structure, mechanism and inhibition

    Saturday, December 04, 2021
    Author(s): Jacqueto Zephyr,Nese Kurt Yilmaz,Celia A Schiffer
    Source: The Enzymes
  • Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

    Thursday, September 23, 2021
    Author(s): Mariana Paes Dias,Vivek Tripathi,Ingrid van der Heijden,Ke Cong,Eleni-Maria Manolika,Jinhyuk Bhin,Ewa Gogola,Panagiotis Galanos,Stefano Annunziato,Cor Lieftink,Miguel Andújar-Sánchez,Sanjiban Chakrabarty,Graeme C M Smith,Marieke van de Ven,Roderick L Beijersbergen,Jirina Bartkova,Sven Rottenberg,Sharon Cantor,Jiri Bartek,Arnab Ray Chaudhuri,Jos Jonkers
    Source: Molecular cell
  • Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis

    Wednesday, September 08, 2021
    Author(s): Sage E Foley,Christine Tuohy,Merran Dunford,Michael J Grey,Heidi De Luca,Caitlin Cawley,Rose L Szabady,Ana Maldonado-Contreras,Jean Marie Houghton,Doyle V Ward,Randall J Mrsny,Beth A McCormick
    Source: Microbiome
  • Revisiting the BRCA-pathway through the lens of replication gap suppression: "Gaps determine therapy response in BRCA mutant cancer"

    Sunday, August 22, 2021
    Author(s): Sharon B Cantor
    Source: DNA repair
  • Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants

    Wednesday, August 18, 2021
    Author(s): Desaboini Nageswara Rao,Jacqueto Zephyr,Mina Henes,Elise T Chan,Ashley N Matthew,Adam K Hedger,Hasahn L Conway,Mohsan Saeed,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
    Source: Journal of medicinal chemistry
  • Rapid signaling reactivation after targeted BRAF inhibition predicts the proliferation of individual melanoma cells from an isogenic population

    Friday, July 30, 2021
    Author(s): Payam Khoshkenar,Emily Lowry,Amir Mitchell
    Source: Scientific reports
  • Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

    Saturday, July 03, 2021
    Author(s): Ke Cong,Min Peng,Arne Nedergaard Kousholt,Wei Ting C Lee,Silviana Lee,Sumeet Nayak,John Krais,Pamela S VanderVere-Carozza,Katherine S Pawelczak,Jennifer Calvo,Nicholas J Panzarino,John J Turchi,Neil Johnson,Jos Jonkers,Eli Rothenberg,Sharon B Cantor
    Source: Molecular cell
  • Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning

    Thursday, June 17, 2021
    Author(s): Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Journal of chemical information and modeling
  • Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning

    Tuesday, March 30, 2021
    Author(s): Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Journal of chemical theory and computation
  • Introduction: Drug Resistance

    Wednesday, March 24, 2021
    Author(s): Nese Kurt Yilmaz,Celia A Schiffer
    Source: Chemical reviews
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Friday, February 26, 2021
    Author(s): Daniel J Klionsky,Amal Kamal Abdel-Aziz,Sara Abdelfatah,Mahmoud Abdellatif,Asghar Abdoli,Steffen Abel,Hagai Abeliovich,Marie H Abildgaard,Yakubu Princely Abudu,Abraham Acevedo-Arozena,Iannis E Adamopoulos,Khosrow Adeli,Timon E Adolph,Annagrazia Adornetto,Elma Aflaki,Galila Agam,Anupam Agarwal,Bharat B Aggarwal,Maria Agnello,Patrizia Agostinis,Javed N Agrewala,Alexander Agrotis,Patricia V Aguilar,S Tariq Ahmad,Zubair M Ahmed,Ulises Ahumada-Castro,Sonja Aits,Shu Aizawa,Yunus Akkoc,Tonia Akoumianaki,Hafize Aysin Akpinar,Ahmed M Al-Abd,Lina Al-Akra,Abeer Al-Gharaibeh,Moulay A Alaoui-Jamali,Simon Alberti,Elísabet Alcocer-Gómez,Cristiano Alessandri,Muhammad Ali,M Abdul Alim Al-Bari,Saeb Aliwaini,Javad Alizadeh,Eugènia Almacellas,Alexandru Almasan,Alicia Alonso,Guillermo D Alonso,Nihal Altan-Bonnet,Dario C Altieri,Élida M C Álvarez,Sara Alves,Cristine Alves da Costa,Mazen M Alzaharna,Marialaura Amadio,Consuelo Amantini,Cristina Amaral,Susanna Ambrosio,Amal O Amer,Veena Ammanathan,Zhenyi An,Stig U Andersen,Shaida A Andrabi,Magaiver Andrade-Silva,Allen M Andres,Sabrina Angelini,David Ann,Uche C Anozie,Mohammad Y Ansari,Pedro Antas,Adam Antebi,Zuriñe Antón,Tahira Anwar,Lionel Apetoh,Nadezda Apostolova,Toshiyuki Araki,Yasuhiro Araki,Kohei Arasaki,Wagner L Araújo,Jun Araya,Catherine Arden,Maria-Angeles Arévalo,Sandro Arguelles,Esperanza Arias,Jyothi Arikkath,Hirokazu Arimoto,Aileen R Ariosa,Darius Armstrong-James,Laetitia Arnauné-Pelloquin,Angeles Aroca,Daniela S Arroyo,Ivica Arsov,Rubén Artero,Dalia Maria Lucia Asaro,Michael Aschner,Milad Ashrafizadeh,Osnat Ashur-Fabian,Atanas G Atanasov,Alicia K Au,Patrick Auberger,Holger W Auner,Laure Aurelian,Riccardo Autelli,Laura Avagliano,Yenniffer Ávalos,Sanja Aveic,Célia Alexandra Aveleira,Tamar Avin-Wittenberg,Yucel Aydin,Scott Ayton,Srinivas Ayyadevara,Maria Azzopardi,Misuzu Baba,Jonathan M Backer,Steven K Backues,Dong-Hun Bae,Ok-Nam Bae,Soo Han Bae,Eric H Baehrecke,Ahruem Baek,Seung-Hoon Baek,Sung Hee Baek,Giacinto Bagetta,Agnieszka Bagniewska-Zadworna,Hua Bai,Jie Bai,Xiyuan Bai,Yidong Bai,Nandadulal Bairagi,Shounak Baksi,Teresa Balbi,Cosima T Baldari,Walter Balduini,Andrea Ballabio,Maria Ballester,Salma Balazadeh,Rena Balzan,Rina Bandopadhyay,Sreeparna Banerjee,Sulagna Banerjee,Ágnes Bánréti,Yan Bao,Mauricio S Baptista,Alessandra Baracca,Cristiana Barbati,Ariadna Bargiela,Daniela Barilà,Peter G Barlow,Sami J Barmada,Esther Barreiro,George E Barreto,Jiri Bartek,Bonnie Bartel,Alberto Bartolome,Gaurav R Barve,Suresh H Basagoudanavar,Diane C Bassham,Robert C Bast,Alakananda Basu,Henri Batoko,Isabella Batten,Etienne E Baulieu,Bradley L Baumgarner,Jagadeesh Bayry,Rupert Beale,Isabelle Beau,Florian Beaumatin,Luiz R G Bechara,George R Beck,Michael F Beers,Jakob Begun,Christian Behrends,Georg M N Behrens,Roberto Bei,Eloy Bejarano,Shai Bel,Christian Behl,Amine Belaid,Naïma Belgareh-Touzé,Cristina Bellarosa,Francesca Belleudi,Melissa Belló Pérez,Raquel Bello-Morales,Jackeline Soares de Oliveira Beltran,Sebastián Beltran,Doris Mangiaracina Benbrook,Mykolas Bendorius,Bruno A Benitez,Irene Benito-Cuesta,Julien Bensalem,Martin W Berchtold,Sabina Berezowska,Daniele Bergamaschi,Matteo Bergami,Andreas Bergmann,Laura Berliocchi,Clarisse Berlioz-Torrent,Amélie Bernard,Lionel Berthoux,Cagri G Besirli,Sebastien Besteiro,Virginie M Betin,Rudi Beyaert,Jelena S Bezbradica,Kiran Bhaskar,Ingrid Bhatia-Kissova,Resham Bhattacharya,Sujoy Bhattacharya,Shalmoli Bhattacharyya,Md Shenuarin Bhuiyan,Sujit Kumar Bhutia,Lanrong Bi,Xiaolin Bi,Trevor J Biden,Krikor Bijian,Viktor A Billes,Nadine Binart,Claudia Bincoletto,Asa B Birgisdottir,Geir Bjorkoy,Gonzalo Blanco,Ana Blas-Garcia,Janusz Blasiak,Robert Blomgran,Klas Blomgren,Janice S Blum,Emilio Boada-Romero,Mirta Boban,Kathleen Boesze-Battaglia,Philippe Boeuf,Barry Boland,Pascale Bomont,Paolo Bonaldo,Srinivasa Reddy Bonam,Laura Bonfili,Juan S Bonifacino,Brian A Boone,Martin D Bootman,Matteo Bordi,Christoph Borner,Beat C Bornhauser,Gautam Borthakur,Jürgen Bosch,Santanu Bose,Luis M Botana,Juan Botas,Chantal M Boulanger,Michael E Boulton,Mathieu Bourdenx,Benjamin Bourgeois,Nollaig M Bourke,Guilhem Bousquet,Patricia Boya,Peter V Bozhkov,Luiz H M Bozi,Tolga O Bozkurt,Doug E Brackney,Christian H Brandts,Ralf J Braun,Gerhard H Braus,Roberto Bravo-Sagua,José M Bravo-San Pedro,Patrick Brest,Marie-Agnès Bringer,Alfredo Briones-Herrera,V Courtney Broaddus,Peter Brodersen,Jeffrey L Brodsky,Steven L Brody,Paola G Bronson,Jeff M Bronstein,Carolyn N Brown,Rhoderick E Brown,Patricia C Brum,John H Brumell,Nicola Brunetti-Pierri,Daniele Bruno,Robert J Bryson-Richardson,Cecilia Bucci,Carmen Buchrieser,Marta Bueno,Laura Elisa Buitrago-Molina,Simone Buraschi,Shilpa Buch,J Ross Buchan,Erin M Buckingham,Hikmet Budak,Mauricio Budini,Geert Bultynck,Florin Burada,Joseph R Burgoyne,M Isabel Burón,Victor Bustos,Sabrina Büttner,Elena Butturini,Aaron Byrd,Isabel Cabas,Sandra Cabrera-Benitez,Ken Cadwell,Jingjing Cai,Lu Cai,Qian Cai,Montserrat Cairó,Jose A Calbet,Guy A Caldwell,Kim A Caldwell,Jarrod A Call,Riccardo Calvani,Ana C Calvo,Miguel Calvo-Rubio Barrera,Niels Os Camara,Jacques H Camonis,Nadine Camougrand,Michelangelo Campanella,Edward M Campbell,François-Xavier Campbell-Valois,Silvia Campello,Ilaria Campesi,Juliane C Campos,Olivier Camuzard,Jorge Cancino,Danilo Candido de Almeida,Laura Canesi,Isabella Caniggia,Barbara Canonico,Carles Cantí,Bin Cao,Michele Caraglia,Beatriz Caramés,Evie H Carchman,Elena Cardenal-Muñoz,Cesar Cardenas,Luis Cardenas,Sandra M Cardoso,Jennifer S Carew,Georges F Carle,Gillian Carleton,Silvia Carloni,Didac Carmona-Gutierrez,Leticia A Carneiro,Oliana Carnevali,Julian M Carosi,Serena Carra,Alice Carrier,Lucie Carrier,Bernadette Carroll,A Brent Carter,Andreia Neves Carvalho,Magali Casanova,Caty Casas,Josefina Casas,Chiara Cassioli,Eliseo F Castillo,Karen Castillo,Sonia Castillo-Lluva,Francesca Castoldi,Marco Castori,Ariel F Castro,Margarida Castro-Caldas,Javier Castro-Hernandez,Susana Castro-Obregon,Sergio D Catz,Claudia Cavadas,Federica Cavaliere,Gabriella Cavallini,Maria Cavinato,Maria L Cayuela,Paula Cebollada Rica,Valentina Cecarini,Francesco Cecconi,Marzanna Cechowska-Pasko,Simone Cenci,Victòria Ceperuelo-Mallafré,João J Cerqueira,Janete M Cerutti,Davide Cervia,Vildan Bozok Cetintas,Silvia Cetrullo,Han-Jung Chae,Andrei S Chagin,Chee-Yin Chai,Gopal Chakrabarti,Oishee Chakrabarti,Tapas Chakraborty,Trinad Chakraborty,Mounia Chami,Georgios Chamilos,David W Chan,Edmond Y W Chan,Edward D Chan,H Y Edwin Chan,Helen H Chan,Hung Chan,Matthew T V Chan,Yau Sang Chan,Partha K Chandra,Chih-Peng Chang,Chunmei Chang,Hao-Chun Chang,Kai Chang,Jie Chao,Tracey Chapman,Nicolas Charlet-Berguerand,Samrat Chatterjee,Shail K Chaube,Anu Chaudhary,Santosh Chauhan,Edward Chaum,Frédéric Checler,Michael E Cheetham,Chang-Shi Chen,Guang-Chao Chen,Jian-Fu Chen,Liam L Chen,Leilei Chen,Lin Chen,Mingliang Chen,Mu-Kuan Chen,Ning Chen,Quan Chen,Ruey-Hwa Chen,Shi Chen,Wei Chen,Weiqiang Chen,Xin-Ming Chen,Xiong-Wen Chen,Xu Chen,Yan Chen,Ye-Guang Chen,Yingyu Chen,Yongqiang Chen,Yu-Jen Chen,Yue-Qin Chen,Zhefan Stephen Chen,Zhi Chen,Zhi-Hua Chen,Zhijian J Chen,Zhixiang Chen,Hanhua Cheng,Jun Cheng,Shi-Yuan Cheng,Wei Cheng,Xiaodong Cheng,Xiu-Tang Cheng,Yiyun Cheng,Zhiyong Cheng,Zhong Chen,Heesun Cheong,Jit Kong Cheong,Boris V Chernyak,Sara Cherry,Chi Fai Randy Cheung,Chun Hei Antonio Cheung,King-Ho Cheung,Eric Chevet,Richard J Chi,Alan Kwok Shing Chiang,Ferdinando Chiaradonna,Roberto Chiarelli,Mario Chiariello,Nathalia Chica,Susanna Chiocca,Mario Chiong,Shih-Hwa Chiou,Abhilash I Chiramel,Valerio Chiurchiù,Dong-Hyung Cho,Seong-Kyu Choe,Augustine M K Choi,Mary E Choi,Kamalika Roy Choudhury,Norman S Chow,Charleen T Chu,Jason P Chua,John Jia En Chua,Hyewon Chung,Kin Pan Chung,Seockhoon Chung,So-Hyang Chung,Yuen-Li Chung,Valentina Cianfanelli,Iwona A Ciechomska,Mariana Cifuentes,Laura Cinque,Sebahattin Cirak,Mara Cirone,Michael J Clague,Robert Clarke,Emilio Clementi,Eliana M Coccia,Patrice Codogno,Ehud Cohen,Mickael M Cohen,Tania Colasanti,Fiorella Colasuonno,Robert A Colbert,Anna Colell,Miodrag Čolić,Nuria S Coll,Mark O Collins,María I Colombo,Daniel A Colón-Ramos,Lydie Combaret,Sergio Comincini,Márcia R Cominetti,Antonella Consiglio,Andrea Conte,Fabrizio Conti,Viorica Raluca Contu,Mark R Cookson,Kevin M Coombs,Isabelle Coppens,Maria Tiziana Corasaniti,Dale P Corkery,Nils Cordes,Katia Cortese,Maria do Carmo Costa,Sarah Costantino,Paola Costelli,Ana Coto-Montes,Peter J Crack,Jose L Crespo,Alfredo Criollo,Valeria Crippa,Riccardo Cristofani,Tamas Csizmadia,Antonio Cuadrado,Bing Cui,Jun Cui,Yixian Cui,Yong Cui,Emmanuel Culetto,Andrea C Cumino,Andrey V Cybulsky,Mark J Czaja,Stanislaw J Czuczwar,Stefania D'Adamo,Marcello D'Amelio,Daniela D'Arcangelo,Andrew C D'Lugos,Gabriella D'Orazi,James A da Silva,Hormos Salimi Dafsari,Ruben K Dagda,Yasin Dagdas,Maria Daglia,Xiaoxia Dai,Yun Dai,Yuyuan Dai,Jessica Dal Col,Paul Dalhaimer,Luisa Dalla Valle,Tobias Dallenga,Guillaume Dalmasso,Markus Damme,Ilaria Dando,Nico P Dantuma,April L Darling,Hiranmoy Das,Srinivasan Dasarathy,Santosh K Dasari,Srikanta Dash,Oliver Daumke,Adrian N Dauphinee,Jeffrey S Davies,Valeria A Dávila,Roger J Davis,Tanja Davis,Sharadha Dayalan Naidu,Francesca De Amicis,Karolien De Bosscher,Francesca De Felice,Lucia De Franceschi,Chiara De Leonibus,Mayara G de Mattos Barbosa,Guido R Y De Meyer,Angelo De Milito,Cosimo De Nunzio,Clara De Palma,Mauro De Santi,Claudio De Virgilio,Daniela De Zio,Jayanta Debnath,Brian J DeBosch,Jean-Paul Decuypere,Mark A Deehan,Gianluca Deflorian,James DeGregori,Benjamin Dehay,Gabriel Del Rio,Joe R Delaney,Lea M D Delbridge,Elizabeth Delorme-Axford,M Victoria Delpino,Francesca Demarchi,Vilma Dembitz,Nicholas D Demers,Hongbin Deng,Zhiqiang Deng,Joern Dengjel,Paul Dent,Donna Denton,Melvin L DePamphilis,Channing J Der,Vojo Deretic,Albert Descoteaux,Laura Devis,Sushil Devkota,Olivier Devuyst,Grant Dewson,Mahendiran Dharmasivam,Rohan Dhiman,Diego di Bernardo,Manlio Di Cristina,Fabio Di Domenico,Pietro Di Fazio,Alessio Di Fonzo,Giovanni Di Guardo,Gianni M Di Guglielmo,Luca Di Leo,Chiara Di Malta,Alessia Di Nardo,Martina Di Rienzo,Federica Di Sano,George Diallinas,Jiajie Diao,Guillermo Diaz-Araya,Inés Díaz-Laviada,Jared M Dickinson,Marc Diederich,Mélanie Dieudé,Ivan Dikic,Shiping Ding,Wen-Xing Ding,Luciana Dini,Jelena Dinić,Miroslav Dinic,Albena T Dinkova-Kostova,Marc S Dionne,Jörg H W Distler,Abhinav Diwan,Ian M C Dixon,Mojgan Djavaheri-Mergny,Ina Dobrinski,Oxana Dobrovinskaya,Radek Dobrowolski,Renwick C J Dobson,Jelena Đokić,Serap Dokmeci Emre,Massimo Donadelli,Bo Dong,Xiaonan Dong,Zhiwu Dong,Gerald W Dorn Ii,Volker Dotsch,Huan Dou,Juan Dou,Moataz Dowaidar,Sami Dridi,Liat Drucker,Ailian Du,Caigan Du,Guangwei Du,Hai-Ning Du,Li-Lin Du,André du Toit,Shao-Bin Duan,Xiaoqiong Duan,Sónia P Duarte,Anna Dubrovska,Elaine A Dunlop,Nicolas Dupont,Raúl V Durán,Bilikere S Dwarakanath,Sergey A Dyshlovoy,Darius Ebrahimi-Fakhari,Leopold Eckhart,Charles L Edelstein,Thomas Efferth,Eftekhar Eftekharpour,Ludwig Eichinger,Nabil Eid,Tobias Eisenberg,N Tony Eissa,Sanaa Eissa,Miriam Ejarque,Abdeljabar El Andaloussi,Nazira El-Hage,Shahenda El-Naggar,Anna Maria Eleuteri,Eman S El-Shafey,Mohamed Elgendy,Aristides G Eliopoulos,María M Elizalde,Philip M Elks,Hans-Peter Elsasser,Eslam S Elsherbiny,Brooke M Emerling,N C Tolga Emre,Christina H Eng,Nikolai Engedal,Anna-Mart Engelbrecht,Agnete S T Engelsen,Jorrit M Enserink,Ricardo Escalante,Audrey Esclatine,Mafalda Escobar-Henriques,Eeva-Liisa Eskelinen,Lucile Espert,Makandjou-Ola Eusebio,Gemma Fabrias,Cinzia Fabrizi,Antonio Facchiano,Francesco Facchiano,Bengt Fadeel,Claudio Fader,Alex C Faesen,W Douglas Fairlie,Alberto Falcó,Bjorn H Falkenburger,Daping Fan,Jie Fan,Yanbo Fan,Evandro F Fang,Yanshan Fang,Yognqi Fang,Manolis Fanto,Tamar Farfel-Becker,Mathias Faure,Gholamreza Fazeli,Anthony O Fedele,Arthur M Feldman,Du Feng,Jiachun Feng,Lifeng Feng,Yibin Feng,Yuchen Feng,Wei Feng,Thais Fenz Araujo,Thomas A Ferguson,Álvaro F Fernández,Jose C Fernandez-Checa,Sonia Fernández-Veledo,Alisdair R Fernie,Anthony W Ferrante,Alessandra Ferraresi,Merari F Ferrari,Julio C B Ferreira,Susan Ferro-Novick,Antonio Figueras,Riccardo Filadi,Nicoletta Filigheddu,Eduardo Filippi-Chiela,Giuseppe Filomeni,Gian Maria Fimia,Vittorio Fineschi,Francesca Finetti,Steven Finkbeiner,Edward A Fisher,Paul B Fisher,Flavio Flamigni,Steven J Fliesler,Trude H Flo,Ida Florance,Oliver Florey,Tullio Florio,Erika Fodor,Carlo Follo,Edward A Fon,Antonella Forlino,Francesco Fornai,Paola Fortini,Anna Fracassi,Alessandro Fraldi,Brunella Franco,Rodrigo Franco,Flavia Franconi,Lisa B Frankel,Scott L Friedman,Leopold F Fröhlich,Gema Frühbeck,Jose M Fuentes,Yukio Fujiki,Naonobu Fujita,Yuuki Fujiwara,Mitsunori Fukuda,Simone Fulda,Luc Furic,Norihiko Furuya,Carmela Fusco,Michaela U Gack,Lidia Gaffke,Sehamuddin Galadari,Alessia Galasso,Maria F Galindo,Sachith Gallolu Kankanamalage,Lorenzo Galluzzi,Vincent Galy,Noor Gammoh,Boyi Gan,Ian G Ganley,Feng Gao,Hui Gao,Minghui Gao,Ping Gao,Shou-Jiang Gao,Wentao Gao,Xiaobo Gao,Ana Garcera,Maria Noé Garcia,Verónica E Garcia,Francisco García-Del Portillo,Vega Garcia-Escudero,Aracely Garcia-Garcia,Marina Garcia-Macia,Diana García-Moreno,Carmen Garcia-Ruiz,Patricia García-Sanz,Abhishek D Garg,Ricardo Gargini,Tina Garofalo,Robert F Garry,Nils C Gassen,Damian Gatica,Liang Ge,Wanzhong Ge,Ruth Geiss-Friedlander,Cecilia Gelfi,Pascal Genschik,Ian E Gentle,Valeria Gerbino,Christoph Gerhardt,Kyla Germain,Marc Germain,David A Gewirtz,Elham Ghasemipour Afshar,Saeid Ghavami,Alessandra Ghigo,Manosij Ghosh,Georgios Giamas,Claudia Giampietri,Alexandra Giatromanolaki,Gary E Gibson,Spencer B Gibson,Vanessa Ginet,Edward Giniger,Carlotta Giorgi,Henrique Girao,Stephen E Girardin,Mridhula Giridharan,Sandy Giuliano,Cecilia Giulivi,Sylvie Giuriato,Julien Giustiniani,Alexander Gluschko,Veit Goder,Alexander Goginashvili,Jakub Golab,David C Goldstone,Anna Golebiewska,Luciana R Gomes,Rodrigo Gomez,Rubén Gómez-Sánchez,Maria Catalina Gomez-Puerto,Raquel Gomez-Sintes,Qingqiu Gong,Felix M Goni,Javier González-Gallego,Tomas Gonzalez-Hernandez,Rosa A Gonzalez-Polo,Jose A Gonzalez-Reyes,Patricia González-Rodríguez,Ing Swie Goping,Marina S Gorbatyuk,Nikolai V Gorbunov,Kıvanç Görgülü,Roxana M Gorojod,Sharon M Gorski,Sandro Goruppi,Cecilia Gotor,Roberta A Gottlieb,Illana Gozes,Devrim Gozuacik,Martin Graef,Markus H Gräler,Veronica Granatiero,Daniel Grasso,Joshua P Gray,Douglas R Green,Alexander Greenhough,Stephen L Gregory,Edward F Griffin,Mark W Grinstaff,Frederic Gros,Charles Grose,Angelina S Gross,Florian Gruber,Paolo Grumati,Tilman Grune,Xueyan Gu,Jun-Lin Guan,Carlos M Guardia,Kishore Guda,Flora Guerra,Consuelo Guerri,Prasun Guha,Carlos Guillén,Shashi Gujar,Anna Gukovskaya,Ilya Gukovsky,Jan Gunst,Andreas Günther,Anyonya R Guntur,Chuanyong Guo,Chun Guo,Hongqing Guo,Lian-Wang Guo,Ming Guo,Pawan Gupta,Shashi Kumar Gupta,Swapnil Gupta,Veer Bala Gupta,Vivek Gupta,Asa B Gustafsson,David D Gutterman,Ranjitha H B,Annakaisa Haapasalo,James E Haber,Aleksandra Hać,Shinji Hadano,Anders J Hafrén,Mansour Haidar,Belinda S Hall,Gunnel Halldén,Anne Hamacher-Brady,Andrea Hamann,Maho Hamasaki,Weidong Han,Malene Hansen,Phyllis I Hanson,Zijian Hao,Masaru Harada,Ljubica Harhaji-Trajkovic,Nirmala Hariharan,Nigil Haroon,James Harris,Takafumi Hasegawa,Noor Hasima Nagoor,Jeffrey A Haspel,Volker Haucke,Wayne D Hawkins,Bruce A Hay,Cole M Haynes,Soren B Hayrabedyan,Thomas S Hays,Congcong He,Qin He,Rong-Rong He,You-Wen He,Yu-Ying He,Yasser Heakal,Alexander M Heberle,J Fielding Hejtmancik,Gudmundur Vignir Helgason,Vanessa Henkel,Marc Herb,Alexander Hergovich,Anna Herman-Antosiewicz,Agustín Hernández,Carlos Hernandez,Sergio Hernandez-Diaz,Virginia Hernandez-Gea,Amaury Herpin,Judit Herreros,Javier H Hervás,Daniel Hesselson,Claudio Hetz,Volker T Heussler,Yujiro Higuchi,Sabine Hilfiker,Joseph A Hill,William S Hlavacek,Emmanuel A Ho,Idy H T Ho,Philip Wing-Lok Ho,Shu-Leong Ho,Wan Yun Ho,G Aaron Hobbs,Mark Hochstrasser,Peter H M Hoet,Daniel Hofius,Paul Hofman,Annika Höhn,Carina I Holmberg,Jose R Hombrebueno,Chang-Won Hong Yi-Ren Hong,Lora V Hooper,Thorsten Hoppe,Rastislav Horos,Yujin Hoshida,I-Lun Hsin,Hsin-Yun Hsu,Bing Hu,Dong Hu,Li-Fang Hu,Ming Chang Hu,Ronggui Hu,Wei Hu,Yu-Chen Hu,Zhuo-Wei Hu,Fang Hua,Jinlian Hua,Yingqi Hua,Chongmin Huan,Canhua Huang,Chuanshu Huang,Chuanxin Huang,Chunling Huang,Haishan Huang,Kun Huang,Michael L H Huang,Rui Huang,Shan Huang,Tianzhi Huang,Xing Huang,Yuxiang Jack Huang,Tobias B Huber,Virginie Hubert,Christian A Hubner,Stephanie M Hughes,William E Hughes,Magali Humbert,Gerhard Hummer,James H Hurley,Sabah Hussain,Salik Hussain,Patrick J Hussey,Martina Hutabarat,Hui-Yun Hwang,Seungmin Hwang,Antonio Ieni,Fumiyo Ikeda,Yusuke Imagawa,Yuzuru Imai,Carol Imbriano,Masaya Imoto,Denise M Inman,Ken Inoki,Juan Iovanna,Renato V Iozzo,Giuseppe Ippolito,Javier E Irazoqui,Pablo Iribarren,Mohd Ishaq,Makoto Ishikawa,Nestor Ishimwe,Ciro Isidoro,Nahed 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Jung,Sung-Chul Jung,Yong Keun Jung,Heinz Jungbluth,Johannes Jungverdorben,Steffen Just,Kai Kaarniranta,Allen Kaasik,Tomohiro Kabuta,Daniel Kaganovich,Alon Kahana,Renate Kain,Shinjo Kajimura,Maria Kalamvoki,Manjula Kalia,Danuta S Kalinowski,Nina Kaludercic,Ioanna Kalvari,Joanna Kaminska,Vitaliy O Kaminskyy,Hiromitsu Kanamori,Keizo Kanasaki,Chanhee Kang,Rui Kang,Sang Sun Kang,Senthilvelrajan Kaniyappan,Tomotake Kanki,Thirumala-Devi Kanneganti,Anumantha G Kanthasamy,Arthi Kanthasamy,Marc Kantorow,Orsolya Kapuy,Michalis V Karamouzis,Md Razaul Karim,Parimal Karmakar,Rajesh G Katare,Masaru Kato,Stefan H E Kaufmann,Anu Kauppinen,Gur P Kaushal,Susmita Kaushik,Kiyoshi Kawasaki,Kemal Kazan,Po-Yuan Ke,Damien J Keating,Ursula Keber,John H Kehrl,Kate E Keller,Christian W Keller,Jongsook Kim Kemper,Candia M Kenific,Oliver Kepp,Stephanie Kermorgant,Andreas Kern,Robin Ketteler,Tom G Keulers,Boris Khalfin,Hany Khalil,Bilon Khambu,Shahid Y Khan,Vinoth Kumar Megraj Khandelwal,Rekha Khandia,Widuri Kho,Noopur V Khobrekar,Sataree Khuansuwan,Mukhran Khundadze,Samuel A Killackey,Dasol Kim,Deok Ryong Kim,Do-Hyung Kim,Dong-Eun Kim,Eun Young Kim,Eun-Kyoung Kim,Hak-Rim Kim,Hee-Sik Kim,None Hyung-Ryong Kim,Jeong Hun Kim,Jin Kyung Kim,Jin-Hoi Kim,Joungmok Kim,Ju Hwan Kim,Keun Il Kim,Peter K Kim,Seong-Jun Kim,Scot R Kimball,Adi Kimchi,Alec C Kimmelman,Tomonori Kimura,Matthew A King,Kerri J Kinghorn,Conan G Kinsey,Vladimir Kirkin,Lorrie A Kirshenbaum,Sergey L Kiselev,Shuji Kishi,Katsuhiko Kitamoto,Yasushi Kitaoka,Kaio Kitazato,Richard N Kitsis,Josef T Kittler,Ole Kjaerulff,Peter S Klein,Thomas Klopstock,Jochen Klucken,Helene Knævelsrud,Roland L Knorr,Ben C B Ko,Fred Ko,Jiunn-Liang Ko,Hotaka Kobayashi,Satoru Kobayashi,Ina Koch,Jan C Koch,Ulrich Koenig,Donat Kögel,Young Ho Koh,Masato Koike,Sepp D Kohlwein,Nur M Kocaturk,Masaaki Komatsu,Jeannette König,Toru Kono,Benjamin T Kopp,Tamas Korcsmaros,Gözde Korkmaz,Viktor I Korolchuk,Mónica Suárez Korsnes,Ali Koskela,Janaiah Kota,Yaichiro Kotake,Monica L Kotler,Yanjun Kou,Michael I Koukourakis,Evangelos Koustas,Attila L Kovacs,Tibor Kovács,Daisuke Koya,Tomohiro Kozako,Claudine Kraft,Dimitri Krainc,Helmut Krämer,Anna D Krasnodembskaya,Carole Kretz-Remy,Guido Kroemer,Nicholas T Ktistakis,Kazuyuki Kuchitsu,Sabine Kuenen,Lars Kuerschner,Thomas Kukar,Ajay Kumar,Ashok Kumar,Deepak Kumar,Dhiraj Kumar,Sharad Kumar,Shinji Kume,Caroline Kumsta,Chanakya N Kundu,Mondira Kundu,Ajaikumar B Kunnumakkara,Lukasz Kurgan,Tatiana G Kutateladze,Ozlem Kutlu,SeongAe Kwak,Ho Jeong Kwon,Taeg Kyu Kwon,Yong Tae Kwon,Irene Kyrmizi,Albert La Spada,Patrick Labonté,Sylvain Ladoire,Ilaria Laface,Frank Lafont,Diane C Lagace,Vikramjit Lahiri,Zhibing Lai,Angela S Laird,Aparna Lakkaraju,Trond Lamark,Sheng-Hui Lan,Ane Landajuela,Darius J R Lane,Jon D Lane,Charles H Lang,Carsten Lange,Ülo Langel,Rupert Langer,Pierre Lapaquette,Jocelyn Laporte,Nicholas F LaRusso,Isabel Lastres-Becker,Wilson Chun Yu Lau,Gordon W Laurie,Sergio Lavandero,Betty Yuen Kwan Law,Helen Ka-Wai Law,Rob Layfield,Weidong Le,Herve Le Stunff,Alexandre Y Leary,Jean-Jacques Lebrun,Lionel Y W Leck,Jean-Philippe Leduc-Gaudet,Changwook Lee,Chung-Pei Lee,Da-Hye Lee,Edward B Lee,Erinna F Lee,Gyun Min Lee,He-Jin Lee,Heung Kyu Lee,Jae Man Lee,Jason S Lee,Jin-A Lee,Joo-Yong Lee,Jun Hee Lee,Michael Lee,Min Goo Lee,Min Jae Lee,Myung-Shik Lee,Sang Yoon Lee,Seung-Jae Lee,Stella Y Lee,Sung Bae Lee,Won Hee Lee,Ying-Ray Lee,Yong-Ho Lee,Youngil Lee,Christophe Lefebvre,Renaud Legouis,Yu L Lei,Yuchen Lei,Sergey Leikin,Gerd Leitinger,Leticia Lemus,Shuilong Leng,Olivia Lenoir,Guido Lenz,Heinz Josef Lenz,Paola Lenzi,Yolanda León,Andréia M Leopoldino,Christoph Leschczyk,Stina Leskelä,Elisabeth Letellier,Chi-Ting Leung,Po Sing Leung,Jeremy S Leventhal,Beth Levine,Patrick A Lewis,Klaus Ley,Bin Li,Da-Qiang Li,Jianming Li,Jing Li,Jiong Li,Ke Li,Liwu Li,Mei Li,Min Li,Min Li,Ming Li,Mingchuan Li,Pin-Lan Li,Ming-Qing Li,Qing Li,Sheng Li,Tiangang Li,Wei Li,Wenming Li,Xue Li,Yi-Ping Li,Yuan Li,Zhiqiang Li,Zhiyong Li,Zhiyuan Li,Jiqin Lian,Chengyu Liang,Qiangrong Liang,Weicheng Liang,Yongheng Liang,YongTian Liang,Guanghong Liao,Lujian Liao,Mingzhi Liao,Yung-Feng Liao,Mariangela Librizzi,Pearl P Y Lie,Mary A Lilly,Hyunjung J Lim,Thania R R Lima,Federica Limana,Chao Lin,Chih-Wen Lin,Dar-Shong Lin,Fu-Cheng Lin,Jiandie D Lin,Kurt M Lin,Kwang-Huei Lin,Liang-Tzung Lin,Pei-Hui Lin,Qiong Lin,Shaofeng Lin,Su-Ju Lin,Wenyu Lin,Xueying Lin,Yao-Xin Lin,Yee-Shin Lin,Rafael Linden,Paula Lindner,Shuo-Chien Ling,Paul Lingor,Amelia K Linnemann,Yih-Cherng Liou,Marta M Lipinski,Saška Lipovšek,Vitor A Lira,Natalia Lisiak,Paloma B Liton,Chao Liu,Ching-Hsuan Liu,Chun-Feng Liu,Cui Hua Liu,Fang Liu,Hao Liu,Hsiao-Sheng Liu,Hua-Feng Liu,Huifang Liu,Jia Liu,Jing Liu,Julia Liu,Leyuan Liu,Longhua Liu,Meilian Liu,Qin Liu,Wei Liu,Wende Liu,Xiao-Hong Liu,Xiaodong Liu,Xingguo Liu,Xu Liu,Xuedong Liu,Yanfen Liu,Yang Liu,Yang Liu,Yueyang Liu,Yule Liu,J Andrew Livingston,Gerard Lizard,Jose M Lizcano,Senka 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F Macleod,Sandra Maday,Frank Madeo,Muniswamy Madesh,Tobias Madl,Julio Madrigal-Matute,Akiko Maeda,Yasuhiro Maejima,Marta Magarinos,Poornima Mahavadi,Emiliano Maiani,Kenneth Maiese,Panchanan Maiti,Maria Chiara Maiuri,Barbara Majello,Michael B Major,Elena Makareeva,Fayaz Malik,Karthik Mallilankaraman,Walter Malorni,Alina Maloyan,Najiba Mammadova,Gene Chi Wai Man,Federico Manai,Joseph D Mancias,Eva-Maria Mandelkow,Michael A Mandell,Angelo A Manfredi,Masoud H Manjili,Ravi Manjithaya,Patricio Manque,Bella B Manshian,Raquel Manzano,Claudia Manzoni,Kai Mao,Cinzia Marchese,Sandrine Marchetti,Anna Maria Marconi,Fabrizio Marcucci,Stefania Mardente,Olga A Mareninova,Marta Margeta,Muriel Mari,Sara Marinelli,Oliviero Marinelli,Guillermo Mariño,Sofia Mariotto,Richard S Marshall,Mark R Marten,Sascha Martens,Alexandre P J Martin,Katie R Martin,Sara Martin,Shaun Martin,Adrián Martín-Segura,Miguel A Martín-Acebes,Inmaculada Martin-Burriel,Marcos Martin-Rincon,Paloma Martin-Sanz,José A Martina,Wim Martinet,Aitor Martinez,Ana Martinez,Jennifer Martinez,Moises Martinez Velazquez,Nuria Martinez-Lopez,Marta Martinez-Vicente,Daniel O Martins,Joilson O Martins,Waleska K Martins,Tania Martins-Marques,Emanuele Marzetti,Shashank Masaldan,Celine Masclaux-Daubresse,Douglas G Mashek,Valentina Massa,Lourdes Massieu,Glenn R Masson,Laura Masuelli,Anatoliy I Masyuk,Tetyana V Masyuk,Paola Matarrese,Ander Matheu,Satoaki Matoba,Sachiko Matsuzaki,Pamela Mattar,Alessandro Matte,Domenico Mattoscio,José L Mauriz,Mario Mauthe,Caroline Mauvezin,Emanual Maverakis,Paola Maycotte,Johanna Mayer,Gianluigi Mazzoccoli,Cristina Mazzoni,Joseph R Mazzulli,Nami McCarty,Christine McDonald,Mitchell R McGill,Sharon L McKenna,BethAnn McLaughlin,Fionn McLoughlin,Mark A McNiven,Thomas G McWilliams,Fatima Mechta-Grigoriou,Tania Catarina Medeiros,Diego L Medina,Lynn A Megeney,Klara Megyeri,Maryam Mehrpour,Jawahar L Mehta,Alfred J Meijer,Annemarie H Meijer,Jakob Mejlvang,Alicia Meléndez,Annette Melk,Gonen 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Zhou,Kailiang Zhou,Rongjia Zhou,Xu-Jie Zhou,Yanshuang Zhou,Yinghong Zhou,Yubin Zhou,Zheng-Yu Zhou,Zhou Zhou,Binglin Zhu,Changlian Zhu,Guo-Qing Zhu,Haining Zhu,Hongxin Zhu,Hua Zhu,Wei-Guo Zhu,Yanping Zhu,Yushan Zhu,Haixia Zhuang,Xiaohong Zhuang,Katarzyna Zientara-Rytter,Christine M Zimmermann,Elena Ziviani,Teresa Zoladek,Wei-Xing Zong,Dmitry B Zorov,Antonio Zorzano,Weiping Zou,Zhen Zou,Zhengzhi Zou,Steven Zuryn,Werner Zwerschke,Beate Brand-Saberi,X Charlie Dong,Chandra Shekar Kenchappa,Zuguo Li,Yong Lin,Shigeru Oshima,Yueguang Rong,Judith C Sluimer,Christina L Stallings,Chun-Kit Tong
    Source: Autophagy
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    Author(s): Jennifer A Calvo,Briana Fritchman,Desiree Hernandez,Nicole S Persky,Cory M Johannessen,Federica Piccioni,Brian A Kelch,Sharon B Cantor
    Source: Molecular cancer research : MCR
  • Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond

    Thursday, January 07, 2021
    Author(s): Ashley N Matthew,Florian Leidner,Gordon J Lockbaum,Mina Henes,Jacqueto Zephyr,Shurong Hou,Desaboini Nageswara Rao,Jennifer Timm,Linah N Rusere,Debra A Ragland,Janet L Paulsen,Kristina Prachanronarong,Djade I Soumana,Ellen A Nalivaika,Nese Kurt Yilmaz,Akbar Ali,Celia A Schiffer
    Source: Chemical reviews
  • A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

    Friday, December 18, 2020
    Author(s): Myoung Sook Han,Rachel J Perry,João-Paulo Camporez,Philipp E Scherer,Gerald I Shulman,Guangping Gao,Roger J Davis
    Source: Genes & development
  • Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

    Monday, November 30, 2020
    Author(s): Brittany Rosener,Serkan Sayin,Peter O Oluoch,Aurian P García González,Hirotada Mori,Albertha Jm Walhout,Amir Mitchell
    Source: eLife
  • FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links

    Sunday, August 16, 2020
    Author(s): Sanket Awate,Joshua A Sommers,Arindam Datta,Sumeet Nayak,Marina A Bellani,Olivia Yang,Christopher A Dunn,Claudia M Nicolae,George-Lucian Moldovan,Michael M Seidman,Sharon B Cantor,Robert M Brosh
    Source: Nucleic acids research
  • JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma

    Wednesday, July 01, 2020
    Author(s): Elisa Manieri,Cintia Folgueira,María Elena Rodríguez,Luis Leiva-Vega,Laura Esteban-Lafuente,Chaobo Chen,Francisco Javier Cubero,Tamera Barrett,Julie Cavanagh-Kyros,Davide Seruggia,Alejandro Rosell,Fátima Sanchez-Cabo,Manuel Jose Gómez,Maria J Monte,Jose J G Marin,Roger J Davis,Alfonso Mora,Guadalupe Sabio
    Source: Proceedings of the National Academy of Sciences of the United States of America
  • Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

    Friday, April 03, 2020
    Author(s): Ashley N Matthew,Jacqueto Zephyr,Desaboini Nageswara Rao,Mina Henes,Wasih Kamran,Klajdi Kosovrasti,Adam K Hedger,Gordon J Lockbaum,Jennifer Timm,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: mBio
  • Microcin H47: A Class IIb Microcin with Potent Activity Against Multidrug Resistant Enterobacteriaceae

    Wednesday, February 26, 2020
    Author(s): Jacob D Palmer,Benedikt M Mortzfeld,Emma Piattelli,Mark W Silby,Beth A McCormick,Vanni Bucci
    Source: ACS infectious diseases
  • Reduction of Inappropriate Antibiotic Use and Improved Outcomes by Implementation of an Algorithm-Based Clinical Guideline for Nonpurulent Skin and Soft Tissue Infections

    Tuesday, February 18, 2020
    Author(s): John P Haran,Melissa Goulding,Maureen Campion,Gail Scully,Arnav Chandra,Rebecca Goldberg,Allyson Day,Emily McLendon,Melissa A Clark
    Source: Annals of emergency medicine
  • Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease

    Friday, December 27, 2019
    Author(s): Troy W Whitfield,Debra A Ragland,Konstantin B Zeldovich,Celia A Schiffer
    Source: Journal of chemical theory and computation
  • Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir

    Tuesday, December 24, 2019
    Author(s): Jennifer Timm,Klajdi Kosovrasti,Mina Henes,Florian Leidner,Shurong Hou,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: ACS chemical biology
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury

    Friday, September 06, 2019
    Author(s): Sanda Win,Robert Wm Min,Christopher Q Chen,Jun Zhang,Yibu Chen,Meng Li,Ayako Suzuki,Manal F Abdelmalek,Ying Wang,Mariam Aghajan,Filbert Wm Aung,Anna Mae Diehl,Roger J Davis,Tin A Than,Neil Kaplowitz
    Source: The Journal of clinical investigation
  • Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

    Thursday, August 29, 2019
    Author(s): Anne Margriet Heijink,Marieke Everts,Megan E Honeywell,Ryan Richards,Yannick P Kok,Elisabeth G E de Vries,Michael J Lee,Marcel A T M van Vugt
    Source: Cell reports
  • HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope

    Wednesday, August 07, 2019
    Author(s): Linah N Rusere,Gordon J Lockbaum,Sook-Kyung Lee,Mina Henes,Klajdi Kosovrasti,Ean Spielvogel,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
    Source: Journal of medicinal chemistry
  • Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance

    Wednesday, July 31, 2019
    Author(s): Mina Henes,Gordon J Lockbaum,Klajdi Kosovrasti,Florian Leidner,Gily S Nachum,Ellen A Nalivaika,Sook-Kyung Lee,Ean Spielvogel,Shuntai Zhou,Ronald Swanstrom,Daniel N A Bolon,Nese Kurt Yilmaz,Celia A Schiffer
    Source: ACS chemical biology
  • Gut Colonization Preceding Mucosal Barrier Injury Bloodstream Infection in Pediatric Hematopoietic Stem Cell Transplantation Recipients

    Monday, July 22, 2019
    Author(s): Matthew S Kelly,Doyle V Ward,Christopher J Severyn,Mehreen Arshad,Sarah M Heston,Kirsten Jenkins,Paul L Martin,Lauren McGill,Andre Stokhuyzen,Shakti K Bhattarai,Vanni Bucci,Patrick C Seed
    Source: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  • The discontinuation of contact precautions for methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus: Impact upon patient adverse events and hospital operations

    Saturday, July 20, 2019
    Author(s): Gregory M Schrank,Graham M Snyder,Roger B Davis,Westyn Branch-Elliman,Sharon B Wright
    Source: BMJ quality & safety
  • NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations

    Friday, June 28, 2019
    Author(s): Rieko Ishima,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Journal of biomolecular NMR
  • Harnessing robotic automation and web-based technologies to modernize scientific outreach

    Thursday, June 27, 2019
    Author(s): Orna Dahan,Bat-Shahar Dorfman,Serkan Sayin,Brittany Rosener,Tiffany Hua,Anat Yarden,Amir Mitchell
    Source: PLoS biology
  • Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

    Wednesday, May 01, 2019
    Author(s): M Michael Dcona,Priyadarshan K Damle,Francisco Zarate-Perez,Benjamin L Morris,Zaid Nawaz,Michael J Dennis,Xiaoyan Deng,Sudha Korwar,Sahib J Singh,Keith C Ellis,William E Royer,Dipankar Bandyopadhyay,Carlos Escalante,Steven R Grossman
    Source: Molecular pharmacology
  • Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors

    Saturday, March 02, 2019
    Author(s): Ayşegül Özen,Kristina Prachanronarong,Ashley N Matthew,Djade I Soumana,Celia A Schiffer
    Source: Critical reviews in biochemistry and molecular biology
  • Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease

    Friday, December 14, 2018
    Author(s): Gordon J Lockbaum,Florian Leidner,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Gily S Nachum,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: ACS infectious diseases
  • Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

    Friday, November 02, 2018
    Author(s): Kristina L Prachanronarong,Aneth S Canale,Ping Liu,Mohan Somasundaran,Shurong Hou,Yu-Ping Poh,Thomas Han,Quan Zhu,Nicholas Renzette,Konstantin B Zeldovich,Timothy F Kowalik,Nese Kurt-Yilmaz,Jeffrey D Jensen,Daniel N A Bolon,Wayne A Marasco,Robert W Finberg,Celia A Schiffer,Jennifer P Wang
    Source: Journal of virology
  • A call to arms: Unifying the fight against resistance

    Thursday, October 25, 2018
    Author(s): Alexis Kaushansky,Lizbeth Hedstrom,Aaron Goldman,Juswinder Singh,Priscilla L Yang,Pradipsinh K Rathod,Michael Cynamon,Dominik Wodarz,Daruka Mahadevan,Andrew Tomaras,Manuel A Navia,Celia A Schiffer
    Source: Science signaling
  • Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease

    Tuesday, August 28, 2018
    Author(s): Ashley N Matthew,Florian Leidner,Alicia Newton,Christos J Petropoulos,Wei Huang,Akbar Ali,Nese KurtYilmaz,Celia A Schiffer
    Source: Structure (London, England : 1993)
  • Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells

    Wednesday, August 08, 2018
    Author(s): Benjamin D Landry,Thomas Leete,Ryan Richards,Peter Cruz-Gordillo,Hannah R Schwartz,Megan E Honeywell,Gary Ren,Alyssa D Schwartz,Shelly R Peyton,Michael J Lee
    Source: Molecular systems biology
  • Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants

    Tuesday, July 24, 2018
    Author(s): Linah N Rusere,Ashley N Matthew,Gordon J Lockbaum,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
    Source: ACS medicinal chemistry letters
  • Macrolide Resistance in Cases of Community-Acquired Bacterial Pneumonia in the Emergency Department

    Thursday, May 24, 2018
    Author(s): John P Haran,Gregory A Volturo
    Source: The Journal of emergency medicine
  • Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease

    Saturday, March 24, 2018
    Author(s): Florian Leidner,Nese Kurt Yilmaz,Janet Paulsen,Yves A Muller,Celia A Schiffer
    Source: Journal of chemical theory and computation
  • Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance

    Tuesday, February 20, 2018
    Author(s): Shahid N Khan,John D Persons,Janet L Paulsen,Michel Guerrero,Celia A Schiffer,Nese Kurt-Yilmaz,Rieko Ishima
    Source: Biochemistry
  • Evolutionary mechanisms studied through protein fitness landscapes

    Sunday, January 21, 2018
    Author(s): Aneth S Canale,Pamela A Cote-Hammarlof,Julia M Flynn,Daniel Na Bolon
    Source: Current opinion in structural biology
  • Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity

    Saturday, December 16, 2017
    Author(s): Jong Hun Kim,Eunjung Lee,Randall H Friedline,Sujin Suk,Dae Young Jung,Sezin Dagdeviren,Xiaodi Hu,Kunikazu Inashima,Hye Lim Noh,Jung Yeon Kwon,Aya Nambu,Jun R Huh,Myoung Sook Han,Roger J Davis,Amy S Lee,Ki Won Lee,Jason K Kim
    Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • Hepatic Dysfunction Caused by Consumption of a High-Fat Diet

    Saturday, December 16, 2017
    Author(s): Anthony R Soltis,Norman J Kennedy,Xiaofeng Xin,Feng Zhou,Scott B Ficarro,Yoon Sing Yap,Bryan J Matthews,Douglas A Lauffenburger,Forest M White,Jarrod A Marto,Roger J Davis,Ernest Fraenkel
    Source: Cell reports
  • CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy

    Sunday, October 29, 2017
    Author(s): Leyuan Ma,Jeffrey I Boucher,Janet Paulsen,Sebastian Matuszewski,Christopher A Eide,Jianhong Ou,Garrett Eickelberg,Richard D Press,Lihua Julie Zhu,Brian J Druker,Susan Branford,Scot A Wolfe,Jeffrey D Jensen,Celia A Schiffer,Michael R Green,Daniel N Bolon
    Source: Proceedings of the National Academy of Sciences of the United States of America
  • A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress

    Thursday, September 21, 2017
    Author(s): Shashi Kant,Claire L Standen,Caroline Morel,Dae Young Jung,Jason K Kim,Wojciech Swat,Richard A Flavell,Roger J Davis
    Source: Cell reports
  • The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

    Friday, September 01, 2017
    Author(s): Louise Ormond,Ping Liu,Sebastian Matuszewski,Nicholas Renzette,Claudia Bank,Konstantin Zeldovich,Daniel N Bolon,Timothy F Kowalik,Robert W Finberg,Jeffrey D Jensen,Jennifer P Wang
    Source: Genome biology and evolution
  • Randomized Comparison of 3 High-Level Disinfection and Sterilization Procedures for Duodenoscopes

    Monday, July 17, 2017
    Author(s): Graham M Snyder,Sharon B Wright,Anne Smithey,Meir Mizrahi,Michelle Sheppard,Elizabeth B Hirsch,Ram Chuttani,Riley Heroux,David S Yassa,Lovisa B Olafsdottir,Roger B Davis,Jiannis Anastasiou,Vijay Bapat,Kiran Bidari,Douglas K Pleskow,Daniel Leffler,Benjamin Lane,Alice Chen,Howard S Gold,Anthony Bartley,Aleah D King,Mandeep S Sawhney
    Source: Gastroenterology
  • Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants

    Friday, June 09, 2017
    Author(s): Ashley N Matthew,Jacqueto Zephyr,Caitlin J Hill,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt-Yilmaz,Celia A Schiffer,Akbar Ali
    Source: Journal of medicinal chemistry
  • Can a nanoparticle that mimics Salmonella effectively combat tumor chemotherapy resistance?

    Wednesday, March 22, 2017
    Author(s): Regino Mercado-Lubo,Beth A McCormick
    Source: Nanomedicine (London, England)
  • An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

    Sunday, August 28, 2016
    Author(s): Claudia Bank,Nicholas Renzette,Ping Liu,Sebastian Matuszewski,Hyunjin Shim,Matthieu Foll,Daniel N A Bolon,Konstantin B Zeldovich,Timothy F Kowalik,Robert W Finberg,Jennifer P Wang,Jeffrey D Jensen
    Source: Evolution; international journal of organic evolution
  • Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease

    Friday, August 12, 2016
    Author(s): Djadé I Soumana,Nese Kurt Yilmaz,Akbar Ali,Kristina L Prachanronarong,Celia A Schiffer
    Source: Journal of the American Chemical Society
  • A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

    Tuesday, July 26, 2016
    Author(s): Regino Mercado-Lubo,Yuanwei Zhang,Liang Zhao,Kyle Rossi,Xiang Wu,Yekui Zou,Antonio Castillo,Jack Leonard,Rita Bortell,Dale L Greiner,Leonard D Shultz,Gang Han,Beth A McCormick
    Source: Nature communications
  • Replication fork stability confers chemoresistance in BRCA-deficient cells

    Saturday, July 23, 2016
    Author(s): Arnab Ray Chaudhuri,Elsa Callen,Xia Ding,Ewa Gogola,Alexandra A Duarte,Ji-Eun Lee,Nancy Wong,Vanessa Lafarga,Jennifer A Calvo,Nicholas J Panzarino,Sam John,Amanda Day,Anna Vidal Crespo,Binghui Shen,Linda M Starnes,Julian R de Ruiter,Jeremy A Daniel,Panagiotis A Konstantinopoulos,David Cortez,Sharon B Cantor,Oscar Fernandez-Capetillo,Kai Ge,Jos Jonkers,Sven Rottenberg,Shyam K Sharan,André Nussenzweig
    Source: Nature
  • HIV-1 capsid is involved in post-nuclear entry steps

    Monday, April 25, 2016
    Author(s): Nan-Yu Chen,Lihong Zhou,Paul J Gane,Silvana Opp,Neil J Ball,Giuseppe Nicastro,Madeleine Zufferey,Cindy Buffone,Jeremy Luban,David Selwood,Felipe Diaz-Griffero,Ian Taylor,Ariberto Fassati
    Source: Retrovirology
  • Improving Viral Protease Inhibitors to Counter Drug Resistance

    Wednesday, April 20, 2016
    Author(s): Nese Kurt Yilmaz,Ronald Swanstrom,Celia A Schiffer
    Source: Trends in microbiology
  • Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants

    Tuesday, March 22, 2016
    Author(s): Doyle V Ward,Matthias Scholz,Moreno Zolfo,Diana H Taft,Kurt R Schibler,Adrian Tett,Nicola Segata,Ardythe L Morrow
    Source: Cell reports
  • Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK

    Tuesday, March 08, 2016
    Author(s): Santiago Vernia,Julie Cavanagh-Kyros,Tamera Barrett,Cathy Tournier,Roger J Davis
    Source: Cell reports
  • A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

    Tuesday, December 15, 2015
    Author(s): Li Jiang,Ping Liu,Claudia Bank,Nicholas Renzette,Kristina Prachanronarong,Lutfu S Yilmaz,Daniel R Caffrey,Konstantin B Zeldovich,Celia A Schiffer,Timothy F Kowalik,Jeffrey D Jensen,Robert W Finberg,Jennifer P Wang,Daniel N A Bolon
    Source: Journal of molecular biology
  • Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia

    Wednesday, October 28, 2015
    Author(s): Megan K Proulx,Samantha G Palace,Sumanth Gandra,Brenda Torres,Susan Weir,Tracy Stiles,Richard T Ellison,Jon D Goguen
    Source: The Journal of infectious diseases
  • Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy

    Tuesday, May 12, 2015
    Author(s): Jean Ndjomou,M Josie Corby,Noreena L Sweeney,Alicia M Hanson,Cihan Aydin,Akbar Ali,Celia A Schiffer,Kelin Li,Kevin J Frankowski,Frank J Schoenen,David N Frick
    Source: ACS chemical biology
  • Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5

    Thursday, April 30, 2015
    Author(s): Yongliang Zhang,Thang Nguyen,Peng Tang,Norman J Kennedy,Huipeng Jiao,Mingliang Zhang,Joseph M Reynolds,Anja Jaeschke,Natalia Martin-Orozco,Yeonseok Chung,Wei-min He,Chen Wang,Weiping Jia,Baoxue Ge,Roger J Davis,Richard A Flavell,Chen Dong
    Source: The Journal of biological chemistry
  • Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy

    Tuesday, March 10, 2015
    Author(s): Michael J Lee
    Source: Molecular cell
  • Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4

    Thursday, March 05, 2015
    Author(s): Shawna Guillemette,Ryan W Serra,Min Peng,Janelle A Hayes,Panagiotis A Konstantinopoulos,Michael R Green,Sharon B Cantor
    Source: Genes & development
  • Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution

    Tuesday, February 17, 2015
    Author(s): Nevra Özer,Ayşegül Özen,Celia A Schiffer,Türkan Haliloğlu
    Source: Evolutionary applications
  • Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

    Tuesday, February 10, 2015
    Author(s): Rachel J Perry,João-Paulo G Camporez,Romy Kursawe,Paul M Titchenell,Dongyan Zhang,Curtis J Perry,Michael J Jurczak,Abulizi Abudukadier,Myoung Sook Han,Xian-Man Zhang,Hai-Bin Ruan,Xiaoyong Yang,Sonia Caprio,Susan M Kaech,Hei Sook Sul,Morris J Birnbaum,Roger J Davis,Gary W Cline,Kitt Falk Petersen,Gerald I Shulman
    Source: Cell
  • Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease

    Friday, October 31, 2014
    Author(s): Ayşegül Özen,Kuan-Hung Lin,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Proceedings of the National Academy of Sciences of the United States of America
  • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

    Thursday, October 23, 2014
    Author(s): Charlie G Buffie,Vanni Bucci,Richard R Stein,Peter T McKenney,Lilan Ling,Asia Gobourne,Daniel No,Hui Liu,Melissa Kinnebrew,Agnes Viale,Eric Littmann,Marcel R M van den Brink,Robert R Jenq,Ying Taur,Chris Sander,Justin R Cross,Nora C Toussaint,Joao B Xavier,Eric G Pamer
    Source: Nature
  • Structural analysis of asunaprevir resistance in HCV NS3/4A protease

    Tuesday, September 23, 2014
    Author(s): Djadé I Soumana,Akbar Ali,Celia A Schiffer
    Source: ACS chemical biology
  • Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease

    Wednesday, August 20, 2014
    Author(s): Yufeng Cai,Wazo Myint,Janet L Paulsen,Celia A Schiffer,Rieko Ishima,Nese Kurt Yilmaz
    Source: Journal of chemical theory and computation
  • Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease

    Wednesday, August 06, 2014
    Author(s): Debra A Ragland,Ellen A Nalivaika,Madhavi N L Nalam,Kristina L Prachanronarong,Hong Cao,Rajintha M Bandaranayake,Yufeng Cai,Nese Kurt-Yilmaz,Celia A Schiffer
    Source: Journal of the American Chemical Society
  • The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway

    Tuesday, July 22, 2014
    Author(s): Santiago Vernia,Julie Cavanagh-Kyros,Luisa Garcia-Haro,Guadalupe Sabio,Tamera Barrett,Dae Young Jung,Jason K Kim,Jia Xu,Hennady P Shulha,Manuel Garber,Guangping Gao,Roger J Davis
    Source: Cell metabolism
  • Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses

    Friday, June 27, 2014
    Author(s): Min Peng,Jenny Xie,Anna Ucher,Janet Stavnezer,Sharon B Cantor
    Source: The EMBO journal