Meet the Team
Caroline Lewis Chidley, PhD
Assistant Professor in Molecular Medicine and Metabolomics Core Director
PhD, Biochemistry and Molecular Cell Biology
University College London, UK
Dr. Chidley came to the U.S. for a postdoc in Matthew Vander Heiden’s laboratory at MIT in Cambridge, MA, where her research focused on cancer metabolism. She has been applying LC-MS to biological questions for 12 years, with a focus on high-resolution mass spectrometry, stable isotope tracing experiments, and untargeted metabolomics.
She joined the Program in Molecular Medicine at UMass Chan Medical School in 2022, having previously directed the Metabolite Profiling Core Facility at the Whitehead Institute for Biomedical Research for five years.
Dr. Chidley collaborates with researchers across multiple disciplines to assist them in understanding the metabolic mechanisms underlying their phenotypes of interest. She has contributed to 50 primary research papers, utilizing her expertise in applied biological mass spectrometry.
She specializes in the use of stable isotopes to trace the contribution and fate of metabolites into different metabolic pathways. She collaborates with researchers on projects involving stable isotope tracing to answer complex biological questions. In addition, Dr. Chidley is highly experienced in both untargeted- and targeted-metabolomics using HRAM instrumentation, applying the former to elucidate the role of the CLN3 protein in Batten disease, and the latter to develop a method to accurately quantify the metabolic contents of tumor interstitial fluid in murine cancers – this method can be applied to other complex biological fluids/ matrices, including bacterial co-culture supernatants.
Outside the lab, Caroline enjoys spending time with friends and family, walking her dog, and singing in a choir.
John Haley, PhD
Research Associate IV, Metabolomics
Dr. Haley completed his doctoral training at UMass Chan Medical School, during which he utilized LC-MS and GC-MS-based technologies to investigate the metabolism of brown adipose tissue and the liver in the context of thermogenesis, obesity, and liver disease. He miniaturized a metabolomics method in mice to sample arterial and venous blood, enabling the calculation of metabolite flux across specific tissues, which was previously reserved for larger animals, such as pigs and rats. Dr. Haley has worked with various types of biological materials, including mouse and human tissue and serum, as well as adherent and suspension cells.
He remains interested in the intersection of metabolism and signaling, with a particular focus on metabolic disease and glutamine metabolism. Outside of lab, John enjoys a wide range of activities like sailing, skiing, hiking, cooking, and reading.
Jaedon Sadler, BSc
Research Associate I, Metabolomics
Jaedon graduated from Penn State University with a degree in Biochemistry and Molecular Biology. As an undergraduate researcher, he worked under Dr. Melanie McReynolds, focusing on the Acute Kidney Injury-mediated dysfunction of NAD+ synthesis mechanisms. In his free time, Jaedon enjoys cooking, playing basketball, and spending time with his friends and family.