CryoEM Facility

CryoEM Core Facility - COMING FALL 2016!!

The CRYO-EM facility will host two high-end Transmission Electron Microscopes from FEI company.

The first microscope is a Titan Krios received in collaboration with UMass Chan and Harvard Medical School. This is one of the most well designed, sophisticated high voltage (300kV) TEM in the world. It has not only superb electronic optical system, but also capability to handle cryo specimen sample for automatic, stable and long time data collection. Titan Krios is equipped with the latest Gatan Image Filter (GIF) and Gatan K2 Summit direct electron detector. This combination allows better electron signal to be recorded. This configuration is currently the ideal setup for high resolution, low-dose and cryo-electron microscopy for both single particle and tomography applications.

The second is a new model also from FEI - Talos-Arctica, running at 200kV  purchased by HHMI. It is based on robust FEI Tecnai system with better, Titan-like objective lens system. Similar to the  Titan Krios instrument, it also has an autoloader system to handle multiple cryo specimens. Talos-Arctica will also be equipped with Gatan’s K2 Summit direct electron detector for the best quality image acquisition.

The facility also has additional equipment for sample preparation, including two FEI Vitrobot model Mark IV. 

This newly established and renovated facility is the first in New England and is the direct result of the combined visionary leadership of the UMass Chan Office of Research, Dean and Chancellor, Department Chairs and HHMI Investigators and the support of many structural biology faculty.  

 

For More Information, Contact:

Chen Xu, Ph.D, Core Director
Office: LRB-802
Cell Phone: (774)502-6698
Email: Chen.Xu@umassmed.edu