Instrumentation

Bruker timsTOF Pro 2 with nanoElute UPLC

~quantitative proteomics~

Unlock the power of next-generation proteomics with the Bruker timsTOF Pro 2, a cutting-edge timed ion mobility quadrupole time-of-flight (QTOF) mass spectrometer delivering exceptional sensitivity, speed, and depth. Designed for high-throughput single-shot workflows or deep proteome coverage, it supports flexible nanoflow gradients to meet diverse research needs. Perfect for stable isotope labeling (SILAC) or label-free quantitation, the timsTOF Pro 2 ensures accurate, reproducible results for complex studies. Its integrated PaSER (Parallel Search Engine in Real Time) provides instant qualitative feedback on sample integrity and system performance, enabling confident decisions during acquisition. With DIA-PASEF (Data-Independent Acquisition combined with Parallel Accumulation Serial Fragmentation), this platform delivers comprehensive, unbiased proteome coverage and exceptional reproducibility ideal for large-scale studies and biomarker discovery.

Learn more: Bruker timsTOF Pro 2

Thermo Scientific Orbitrap Fusion Lumos Tribrid with Waters NanoAcquity UPLC

~quantitative proteomics~

A quadrupole-Orbitrap-linear ion trap tribrid mass spectrometer employing HCD, CID and ETD fragmentation options. Instrument is equiped with a FAIMS PRO source for atmospheric ion mobility separations providing improved analyte selectivity and expanded proteome coverage. Analysis of complex protein digests including identification of post-translational modifications, covalently bound protein-drug adducts, and chemically cross-linked peptides. Ideal for stable isotope label (e.g. TMT, SILAC) or label-free (peptide peak area) quantitative proteomics workflows.

Thermo Scientific Q Exactive with Waters NanoAcquity UPLC

~proteomics~

A quadrupole-Orbitrap hybrid mass spectrometer employing HCD fragmentation used for proteomics applications. Analysis of simple and complex protein digests. Ideal for peptide mapping, protein ID or label-free (peptide peak area) quantitative workflows.

Thermo Scientific Q Exactive HF-X with Vanquish Flex UHPLC

~metabolomics profiling and targeted quantitation~

A quadrupole-Orbitrap hybrid mass spectrometer employing HCD fragmentation and conventional flow UHPLC. Metabolomics applications include untargeted metabolomic and lipidomic profiling and targeted assays.

Waters Synapt G2-Si with Acquity UPLC

A quadrupole time-of-flight mass spectrometer enabled with gas-phase ion mobility separations for improved analyte selectivity.

~intact protein, mAb, and oligonucleotide analysis~

• intact and reduced proteins, mAb's, and oligonucleotides analyzed by ESI LC-MS with a Waters Acquity UPLC. UPLC fitted with an inline UV detector.
• nanoflow UPLC options also available.

~mass spectrometry tissue imaging~

• in-situ tissue imaging for mapping the spatial distribution of exogenous drugs or endogenous lipids and metabolites in sectioned tissue.
• Nd:YAG high repetition laser for matrix-assisted laserdesorption/ionization (MALDI) applications.
• HTX Technologies TM-Sprayer for matrix application.
• desorption electrospray ionization (DESI) option available.

Waters Xevo TQ-XS with Acquity UPLC

 ~targeted metabolomics~

A triple quadrupole mass spectrometer for targeted metabolomics and small molecule quantitation using conventional flow UPLC. UPLC fitted with an inline photodiode array detector.

Thermo Scientific TSQ Quantiva with Dionex UltiMate 3000 UHPLC

 ~targeted metabolomics~

A triple quadrupole mass spectrometer for targeted metabolomics and small molecule quantitation using conventional flow UHPLC. A Proxeon EasyLC is also available for nanoflow applications.

Thermo Scientific Orbitrap Velos Pro with Accela 1250 UHPLC or Waters NanoAcquity UPLC

A linear ion trap-Orbitrap hybrid mass spectrometer employing CID, HCD, and ETD fragmentation. Untargeted metabolomic and lipidomic profiling and targeted assays using HCD fragmentation using conventional flow UHPLC. Nanoflow UPLC for high-sensitivity applications including neuroactive steroids, modified nucleotides, and peptides.