Our Studies

The list below represents the currently approved studies for the Division of Gastroenterology at UMass:

A multicenter, multinational, randomized, double-blind, placebo-controlled Phase 3, induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Ulcerative Colitis (SUNSCAPE-1)
Principal Investigator: Abbas Rupawala

A Multicenter, Multinational, Randomized, Double-blind, Placebo-Controlled, Phase 3 Maintenance Study to Evaluate the Efficacy and Safety of Duvakitug in Participants with Moderately to Severely Active Ulcerative Colitis (SUNSCAPE-2)
Principal Investigator: Abbas Rupawala

A multicenter, multinational, randomized, double-blind, placebo-controlled Phase 3, induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Crohn’s Disease (STARSCAPE-1)
Principal Investigator: Abbas Rupawala

A multicenter, multinational, randomized, double-blind, placebo-controlled Phase 3, maintenance study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Crohn’s disease (STARSCAPE-2)
Principal Investigator: Abbas Rupawala

A phase 2b, multicenter, double-blind, placebo-controlled, study to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of obefazimod in subjects with moderately to severely active Crohn’s disease (ENHANCE-CD)
Principal Investigator: Abbas Rupawala

A Phase 4 Study Evaluating Real-World Use of CDPATH(TM), a Crohn's Disease Risk Prediction Tool (COMPASS-CD)
Principal Investigator: Christopher Marshall

A Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Effect of Resmetirom on Liver-related Outcomes in Patients with Well-compensated (Child-Pugh A) Non-alcoholic Steatohepatitis (NASH) Cirrhosis (MGL-3196-19)
Principal Investigator: Anita Krishnarao

A Phase III, Multicenter, Double-Blind, Placebo-Controlled, Induction Only Study to Assess the Efficacy and Safety of Induction Therapy with RO7790121 in Patients with Moderately to Severely Active Crohn's Disease (SIBERITE-2)
Principal Investigator: Abbas Rupawala

Fecal Microbiota Transplant and other Gut Microbial Therapies National Registry
Principal Investigator: Abbas Rupawala

Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium difficile
Principal Investigator: Krunal Patel

Analysis of biologic samples from infectious and inflammatory GI diseases
Principal Investigator: JeanMarie Houghton         

UMass Ulcerative Colitis Registry (UMUC) – Retrospective Cohort
Principal Investigator: Abbas Rupawala

Artificial Intelligence to interpret Intestinal Ultrasound in Inflammatory Bowel Disease (AI IUS IBD)
Principal Investigator: Leo Boneschansker

UMass IBD Registry (UMIR)
Principal Investigator: Leo Boneschansker

Incidence of Serrated Adenomas in Patients with and without Inflammatory Bowel Disease (IBD)
Principal Investigator: Abbas Rupawala

Inflammatory responses and mechanisms in Alcohol Associated Hepatitis (AH)
Principal Investigator: Pranoti Mandrekar

Evaluating Disease Characteristics of Patients with Primary Sclerosing Cholangitis and Coincident Inflammatory Bowel Disease Using a Comprehensive Internal Database (PSC-IBD Database)
Principal Investigator: Navine Nasser-Ghodsi

Real-Time Cholangioscopy Artificial Intelligence Evaluation of Biliary Strictures
Principal Investigator: Neil Marya           

Development and validation of convolutional neural network models for gastrointestinal and pancreaticobiliary diseases
Principal Investigator: Neil Marya           

End of life care for patients with end stage liver disease removed from liver transplantation wait list and those admitted for inpatient transplant evaluation
Principal Investigator: Navine Nasser-Ghodsi

Retrospective Analysis of Acute Cholecystitis Management
Principal Investigator: Neil Marya           

Exploring barriers within the liver transplant evaluation care pathway and evaluating downstream effects
Principal Investigator: Deepika Devuni

Evaluating the relationship between organ rejection and cutaneous malignancy in liver transplant recipients
Principal Investigator: Deepika Devuni

Improving utilization of appropriate consultation for inpatient management of acute alcohol-related hepatitis 
Principal Investigator: Deepika Devuni

Improving collection of women’s health history in female patients undergoing liver transplant evaluation: A quality improvement initiative                                                                                          
Principal Investigator: Deepika Devuni