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Selected Recent Publications

A complete list of published work can be found in  My Bibliography

Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress
Ekaterina Korobkina 1, Camila Martinez Calejman 1, John Haley 1, Miranda Kelly 2, Huawei Li 1, Maria Gaughan 1, Qingbo Chen 1, Hannah Pepper 3, Hafsah Ahmad 3, Alexander Boucher 1, Shelagh Fluharty 1, Te-Yueh Lin 1, Anoushka Lotun 1, Jessica Peura 4, Sophie Trefely 5 6, Courtney Green 7, Paula Vo 1, Clay Semenkovich 8, Jason Pitarresi 4 9, Jessica Spinelli 1, Ozkan Aydemir 1, Christian Metallo 7 10, Matthew Lynes 11, Cholsoon Jang 2, Nathaniel Snyder 3, Kathryn  Wellen 5 6, David Guertin 12 13 Nat Metab, 2024 Nov;6(11):2187-2202. doi: 10.1038/s42255-024-01143-3. Epub 2024 Oct 14. PMID: 39402290, PMCID: PMC11841677, DOI: 10.1038/s42255-024-01143-3

A new era of understanding in vivo metabolic flux in thermogenic adipocytes
Haley JA, Jang C, Guertin DA. Curr Opin Genet Dev. 2023 Dec;83:102112. doi: 10.1016/j.gde.2023.102112. Epub 2023 Sep 11. Review. PubMed PMID: 37703635; PubMed Central PMCID: PMC10840980.

Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis
Park G, Haley JA, Le J, Jung SM, Fitzgibbons TP, Korobkina ED, Li H, Fluharty SM, Chen Q, Spinelli JB, Trivedi CM, Jang C, Guertin DA. Nat Metab. 2023 Jul;5(7):1204-1220. doi: 10.1038/s42255-023-00825-8. Epub 2023 Jun 19. PubMed PMID: 37337122; PubMed Central PMCID: PMC10696589.

Acetyl-CoA Metabolism in Cancer
Guertin DA, Wellen KE. Nat Rev Cancer. 2023 Mar;23(3):156-172. doi: 10.1038/s41568-022-00543-5. Epub 2023 Jan 19. 

In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate 
Jung SM, Doxsey WG, Le J, Haley JA, Mazuecos L, Luciano AK, Li H, Jang C, Guertin DA.
Cell Rep. 2021 Jul 27;36(4):109459. doi: 10.1016/j.celrep.2021.109459. PubMed PMID: 34320357; PubMed Central PMCID: PMC8369932.
The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
Hsiao WY, Jung SM, Tang Y, Haley JA, Li R, Li H, Calejman CM, Sanchez-Gurmaches J, Hung CM, Luciano AK, DeMambro V, Wellen KE, Rosen CJ, Zhu LJ, Guertin DA.
Cell Rep. 2020 Oct 6;33(1):108223. doi: 10.1016/j.celrep.2020.108223. PubMed PMID: 33027655; PubMed Central PMCID: PMC7607535.
mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Villén J, Wellen KE, Guertin DA.
Nat Commun. 2020 Jan 29;11(1):575. doi: 10.1038/s41467-020-14430-w. PubMed PMID: 31996678; PubMed Central PMCID: PMC6989638.

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
Jung SM, Hung CM, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA. 
Mol Cell. 2019 Aug 22;75(4):807-822.e8. doi: 10.1016/j.molcel.2019.07.023. PubMed PMID: 31442424.

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA. 
Cell Metab. 2018 Jan 9;27(1):195-209.e6. doi: 10.1016/j.cmet.2017.10.008. Epub 2017 Nov 16. PubMed PMID: 29153407; PubMed Central PMCID: PMC5762420.