Current Greiner Lab Projects Include:

Modeling Human Tumor Immunotherapy in NSG Mice

Type 1 Diabetes Specialized Mouse Avatars 

Reconstructing type 1 diabetes using human cells derived from T1D patients, in novel immunodeficient "humanized" mice.  These models provide a better understanding of how humans might react to certain factors.

Development & Validation of Novel Mouse Models for Human Stem Cell Therapy

Generating new humanized mouse models for functional in vivo studies of human stem cells and to validate these models by determining the ability of human stem cells to generate functional differentiated human cells and tissues that ameliorate disease.

From New Models to Novel Therapeutics

Co-director with Dr. Michael Brehm of a pre-clinical/co-clinical core to advance the development and use of models of human-specific diseases at UMass Chan Medical School.  The Core is working with The Jackson Laboratory to promote interactions with clinicians and hospitals, access to patient data and samples, and comprehensive model assessment necessary for the generation of models engrafted with human tumors and immune systems for preclinical testing.